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5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa:a Role of Endogenous Peptide YY
https://dmu.repo.nii.ac.jp/records/5061
https://dmu.repo.nii.ac.jp/records/50619da0eecb-42d4-4449-a651-b183ea1c85ea
名前 / ファイル | ライセンス | アクション |
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DJMS-48-2-Kojima-本文 (242.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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タイトル | ||||||
タイトル | 5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa:a Role of Endogenous Peptide YY | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BW723C86 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | guinea-pig colon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-HT2B receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-HT release | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuropeptide Y1 receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peptide YY | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kojima, Ken
× Kojima, Ken× Kojima, Shu-ichi× Fujita, Tomoe |
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著者所属 | ||||||
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||
著者所属 | ||||||
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||
著者所属 | ||||||
Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan | ||||||
書誌情報 |
Dokkyo Journal of Medical Sciences 巻 48, 号 2, p. 81-86, 発行日 2021-07-25 |
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要旨 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Purpose:The effect of 5-HT2B receptor-selective agonist BW723C86 was investigated on the outflow of 5-hydroxytryptamine(5-HT)from isolated muscle layer-free mucosal preparations of guinea-pig colon. Methods:The mucosal preparations were incubated in vitro and the outflow of 5-HT from these preparations was determined by high-performance liquid chromatography with electrochemical detection. Results:BW723C86(1-10 μM)produced a sustained increase in the outflow of 5-HT from the mucosal preparations. The BW723C86-evoked 5-HT outflow was inhibited by the two different 5-HT2B receptor antagonists, olanzapine(100 nM)and RS127445(100 nM). The neuropeptide Y1 receptor antagonist BIBO3304(300 nM)markedly inhibited the BW723C86-evoked 5-HT outflow. Conclusion:We found that 5-HT2B receptor-triggered 5-HT release from guinea-pig colonic mucosa is mediated by the activation of 5-HT2B receptors located at endocrine cells and that the 5-HT2B receptortriggered 5-HT release is mediated by endogenously released peptide YY, acting via Y1 receptors. Given that both 5-HT and peptide YY are well-known mediators of nausea and vomiting, the 5-HT2B receptors located at endocrine cells may play a role in the generation of nausea and vomiting. |
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記事種別 | ||||||
Original | ||||||
出版者 | ||||||
出版者 | 獨協医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00629581 |