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However, no criteria for the classification of `smoker\u0027 and `atopic\u0027 in bronchialasthma have been defined. In this study, we compared the levels of several cytokines found in thebronchoalveolar lavage( BAL) fluid of patients classified as having bronchial asthma.Methods:Cell subpopulations in BAL fluid were counted. BAL fluid levels of interleukin( IL)-4, -5, -13,-17, and -33 and RANTES (regulated on activation, normal T cell expressed and secreted were measuredusing a bead suspension array in 36 asthma patients (13 males, 23 females;mean age, 39.5±92.8 years)who were non-smokers, 18 asthma patients( 11 males, 7 females;mean age, 30.7±2.7 years) who were exor current smokers( Brinkman index( BI):1\u0026#8722;399), and 10 asthma patients( 9 males, 1 female;mean age,50.2±5.5 years) who were current heavy smokers( BI:\u0026#8805; 400). Relationships were assessed by Spearman\u0027srank correlation analysis.Results:The number of lymphocytes in BAL cell subpopulations of non-smokers( 25±7×103/ml) weresignificantly (p\u003c0.05) higher than those of heavy smokers (12±3×103 /ml). The number of neutrophilswas significantly( p\u003c0.05) higher in heavy smokers( 18±9×103/ml) than in non-smokers( 4±2×103/ml).Levels of IL-33 and RANTES were significantly (P\u003c0.05) higher in non-smokers (26.1±7.3 pg/ml and42.8±10.3 pg/ml, respectively) than in heavy smokers (13.7±4.5 pg/ml and 27.4±5.4 pg/ml, respectively).In addition, the levels of IL-33 and RANTES in non-smokers were significantly( P\u003c0.05) higher in atopicasthma patients (33.0±9.8 pg/ml and 47.8±14.0 pg/ml, respectively) than in non-atopic asthma patients(9.1±3.8 pg/ml and 29.5±7.8 pg/ml, respectively). 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IL-33 and RANTES( Regulated on Activation, Normal T Cell Expressed and Secreted) in BAL Fluid in Asthma Patients Without Cigarette Smoking
https://dmu.repo.nii.ac.jp/records/1082
https://dmu.repo.nii.ac.jp/records/1082d3831136-df01-47b5-8f84-f4b52c921eda
名前 / ファイル | ライセンス | アクション |
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KJ00008416399.pdf (1.3 MB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | IL-33 and RANTES( Regulated on Activation, Normal T Cell Expressed and Secreted) in BAL Fluid in Asthma Patients Without Cigarette Smoking | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | BAL fluid | |||||
キーワード | ||||||
言語 | en | |||||
主題 | IL-33 | |||||
キーワード | ||||||
言語 | en | |||||
主題 | RANTES | |||||
キーワード | ||||||
言語 | en | |||||
主題 | asthma | |||||
キーワード | ||||||
言語 | en | |||||
主題 | smoker | |||||
キーワード | ||||||
言語 | en | |||||
主題 | atopy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | IL-33 and RANTES( Regulated on Activation, Normal T Cell Expressed and Secreted) in BAL Fluid in Asthma Patients Without Cigarette Smoking | |||||
著者 |
Tatewaki, Masamitsu
× Tatewaki, Masamitsu× Hirata, Hirokuni× Fukushima, Fumiya× Fukushima, Yasutsugu× Sugiyama, Kumiya× Fukuda, Takeshi |
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著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University | ||||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background:Inflammatory cytokines and chemokines have been reported to play important roles in thepathogenesis of bronchial asthma. However, no criteria for the classification of `smoker' and `atopic' in bronchialasthma have been defined. In this study, we compared the levels of several cytokines found in thebronchoalveolar lavage( BAL) fluid of patients classified as having bronchial asthma.Methods:Cell subpopulations in BAL fluid were counted. BAL fluid levels of interleukin( IL)-4, -5, -13,-17, and -33 and RANTES (regulated on activation, normal T cell expressed and secreted were measuredusing a bead suspension array in 36 asthma patients (13 males, 23 females;mean age, 39.5±92.8 years)who were non-smokers, 18 asthma patients( 11 males, 7 females;mean age, 30.7±2.7 years) who were exor current smokers( Brinkman index( BI):1−399), and 10 asthma patients( 9 males, 1 female;mean age,50.2±5.5 years) who were current heavy smokers( BI:≥ 400). Relationships were assessed by Spearman'srank correlation analysis.Results:The number of lymphocytes in BAL cell subpopulations of non-smokers( 25±7×103/ml) weresignificantly (p<0.05) higher than those of heavy smokers (12±3×103 /ml). The number of neutrophilswas significantly( p<0.05) higher in heavy smokers( 18±9×103/ml) than in non-smokers( 4±2×103/ml).Levels of IL-33 and RANTES were significantly (P<0.05) higher in non-smokers (26.1±7.3 pg/ml and42.8±10.3 pg/ml, respectively) than in heavy smokers (13.7±4.5 pg/ml and 27.4±5.4 pg/ml, respectively).In addition, the levels of IL-33 and RANTES in non-smokers were significantly( P<0.05) higher in atopicasthma patients (33.0±9.8 pg/ml and 47.8±14.0 pg/ml, respectively) than in non-atopic asthma patients(9.1±3.8 pg/ml and 29.5±7.8 pg/ml, respectively). A good correlation was noted between RANTES andlymphocytes (R=0.365, P<0.05) or IL-33 (R=0.561, P<0.05) in atopic asthma patients who were nonsmokers.Conclusions:Differences in the cell types of BAL fluid, as well as in the levels of IL-33 and RANTES inasthma patients with or without smoking, might reflect pathogenesis. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 40, 号 1, p. 27-37, 発行日 2013-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |