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Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II
https://dmu.repo.nii.ac.jp/records/1146
https://dmu.repo.nii.ac.jp/records/114601a4f0de-d183-4ed5-a356-8fbaccf5caba
名前 / ファイル | ライセンス | アクション |
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KJ00008800279.pdf (259.4 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | protein induced by vitamin K absence or antagonist II( PIVKA-II) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | NX-PVKA-R | |||||
キーワード | ||||||
言語 | en | |||||
主題 | hepatocellular carcinoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II | |||||
著者 |
Suzuki, Kazuyoshi
× Suzuki, Kazuyoshi× Tamano, Masaya× Kuniyoshi, Toru× Katayama, Yasumi× Takada, Hiroshi× Suzuki, Kazutomo |
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著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital | ||||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background/Aims:To compare the use of protein induced by vitamin K absence or antagonist II( PIVKA-II) measured conventionally with the ratio between PIVKA-II measured using P-11 and P-16 antibodies(NX-PVKA) and PIVKA-II measured conventionally (NX-PVKA-R) in terms of false-positive resultsfor hepatocellular carcinoma( HCC). Methodology:Subjects comprised 318 patients with chronic liver disease,including 8 patients receiving warfarin treatment, which can result in false-positive results for HCC.HCC was present in 65 patients (HCC group) and absent in 253 (non-HCC group). PIVKA-II was measuredconventionally. NX-PVKA-R was calculated as PIVKA-II/NX-PVKA. Results:Both PIVKA-II andNX-PVKA-R were significantly higher in the HCC group than in the non-HCC group (p<0.0001 each).False-positive results were seen in 9.5% of non-HCC patients with PIVKA-II, and in 10.3% with NX-PVKA-R. False-positive results were seen for all 8 patients (100%) on warfarin with PIVKA-II, but for 0%with NX-PVKA-R. Sensitivity, specificity, and accuracy were all lower for NX-PVKA-R than PIVKA-II.Conclusions:NX-PVKA-R is not more useful than PIVKA-II for diagnosing HCC, but is very useful insubpopulations such as patients on warfarin and patients with jaundice. The characteristics of NX-PVKA-Rcan be best exploited by selecting patients in which these factors are present. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 40, 号 3, p. 163-168, 発行日 2013-10-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |