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Comparison between High-dose Telmisartan and Fixed dose Combination of Telmisartan and Hydrochlorothiazide in Patients with Hypertension
https://dmu.repo.nii.ac.jp/records/1304
https://dmu.repo.nii.ac.jp/records/130416390bf5-1bb0-45ce-806d-1eee37bb063b
名前 / ファイル | ライセンス | アクション |
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KJ00010247940.pdf (207.1 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comparison between High-dose Telmisartan and Fixed dose Combination of Telmisartan and Hydrochlorothiazide in Patients with Hypertension | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Angiotensin Ii Receptor Blocker | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Diuretic, Uric Acid | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Fixed-dose Combination | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Hypertension | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Comparison between High-dose Telmisartan and Fixed dose Combination of Telmisartan and Hydrochlorothiazide in Patients with Hypertension | |||||
著者 |
Murayama, Yoshiki
× Murayama, Yoshiki× Ishimitsu, Toshihiko× Furuichi, Masahito× Ueno, Yasuhiko× Satonaka, Hiroshi |
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著者所属(英) | ||||||
en | ||||||
Department Of Cardiology And Nephrology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department Of Cardiology And Nephrology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department Of Cardiology And Nephrology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department Of Cardiology And Nephrology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department Of Cardiology And Nephrology, Dokkyo Medical University | ||||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | We compared treatment with a high-dose angiotensin II receptor blocker(ARB)and combination of ARB with a thiazide diuretic in 17 patients with hypertension. A randomized crossover study was performed giving 80 mg telmisartan or fixed-dose combination of 40 mg telmisartan and 12.5 mg hydrochlorothiazide for 16 weeks each. Although the clinic blood pressure was comparable between the high-dose ARB period(134/81 mmHg)and the combination period(134/82 mmHg), the morning home blood pressure was lower in the combination period than in the high-dose ARB period(138/82 vs. 151/88 mmHg, p=0.026/0.013). No significant difference was observed in urinary albumin excretion, but estimated glomerular filtration rate was lower in the combination than in the high-dose ARB period(58.9 vs. 62.1 mL/min/1.73 m^2, p=0.039). Serum uric acid was higher in the combination than in the high-dose ARB period(6.7 vs. 5.9 mg/dL p=0.022). The indices of glucose metabolism, serum lipids, oxidative stress, inflammation and adipocytokine did not significantly differ between the two periods. There was no significant difference in the measurement of endothelium-dependent vasodilation between the two periods. It is suggested that the addition of thiazide diuretic to medium-dose ARB is more effective in lengthening the hypotensive effect than high-dose ARB, however, care should be taken for the elevation of serum uric acid and the decrease in renal function. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 43, 号 2, p. 115-123, 発行日 2016-07-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |