WEKO3
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KM生存曲線は高年齢群(p\u003c0.001),高ANP群(p=0.006),高BNP群(p=0.039)で有意に生存期間が短く,心胸比,収縮期血圧,血清アルブミン, PRA, PNAにおいては高低2群間に有意差を認めなかった. Cox比例hazard法による単変量解析では年齢(p\u003c0.001),心胸比(p=0.011), ANP (p=0.003), BNP (p=0.002)が生命予後の有意なリスク因子となり,多変量解析ではp値は年齢\u003c0.001,心胸比0.965, ANP 0.055, BNP 0.041となり,年齢とBNPが生命予後の独立したリスク因子であった.以上より透析患者において透析直後の血漿BNP濃度は長期生命予後の独立したリスク因子であり,血漿ANP濃度もリスク因子としてBNPに次いで重要であることが示された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "This study was designed to clarify the clinical significance of post-dialysis plasma vasoactive substances including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), plasma renin activity (PRA) and noradrenaline (PNA) as a survival predictor in chronic hemo-dialysis (HD) patients. Immediately after HD, blood samples were collected for the measurements of serum albumin, ANP, BNP, PRA and PNA in 52 HD patients. During 15-year follow-up period 43 patients died ; 40 of diseases, 2 accident, 1 suicide. Patients were divided into two groups using the median of their age and clinical and laboratory variables. Kaplan-Meier survival analysis revealed that the groups of older age, higher plasma ANP and BNP concentration had significantly lower survival rates as compared with each counterpart (p\u003c0.001, p=0.006, p=0.039, respectively). Univariate and multivariate Cox proportional hazard regression analyses were used to assess the potential association of their age, and clinical and laboratory variables with a survival rate. As a result of Univariate Cox hazard analysis, age, cardiothoracic ratio (CTR), and plasma ANP, and BNP concentrations had significant relationship with overall mortality (p\u003c0.001, p=0.011, p=0.003, and p=0.002, respectively). However, stepwise multivariate analysis revealed that the significant relationship with overall mortality was shown for their age (p\u003c0.001) and BNP (p=0.041). 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of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiovascular Medicine, University of Tokyo"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Hypertension \u0026 Cardiorenal Medicine, Dokkyo Medical University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "ケツエキ トウセキ カンジャ ノ チョウキ セイメイ ヨゴ ヨソク インシ トシテノ トウセキゴ ノ ケッショウANP ト BNPノウド ノ ユウヨウセイ : 15ネンカン ノ ヨゴ チョウサ "}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "寺西, 恵"}, {"creatorName": "テラニシ, メグミ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "宮下, 和久"}, {"creatorName": "ミヤシタ, カズヒサ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 正志"}, {"creatorName": "スズキ, マサシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": 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[{"creatorName": "平田, 恭信"}, {"creatorName": "ヒラタ, ヤスノブ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松岡, 博昭"}, {"creatorName": "マツオカ, ヒロアキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "2696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teranishi, Megumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyashita, Kazuhisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2698", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Masashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2699", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hurudera, Rie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "2700", "nameIdentifierScheme": 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "hemodialysis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "survival", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atrial natriuretic peptide (ANP)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "brain natriuretic peptide (BNP)", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "血液透析患者の長期生命予後予測因子としての透析後の血漿ANPとBNP濃度の有用性 : 15年間の予後調査", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "血液透析患者の長期生命予後予測因子としての透析後の血漿ANPとBNP濃度の有用性 : 15年間の予後調査"}, {"subitem_title": "Clinical Significance of Post-Dialysis Plasma Concentrations of Atrial Natriuretic Peptide and Brain Natiuretic Peptide as Long-term Survival Predictors in Hemodialysis Patients : 15-year follow up study", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["46"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/675", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "675", "relation": {}, "relation_version_is_last": true, "title": ["血液透析患者の長期生命予後予測因子としての透析後の血漿ANPとBNP濃度の有用性 : 15年間の予後調査"], "weko_shared_id": 3}
血液透析患者の長期生命予後予測因子としての透析後の血漿ANPとBNP濃度の有用性 : 15年間の予後調査
https://dmu.repo.nii.ac.jp/records/675
https://dmu.repo.nii.ac.jp/records/675d256e3de-4580-49ad-b1b7-d57333ed21c0
名前 / ファイル | ライセンス | アクション |
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KJ00005058779.pdf (642.9 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
タイトル | 血液透析患者の長期生命予後予測因子としての透析後の血漿ANPとBNP濃度の有用性 : 15年間の予後調査 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical Significance of Post-Dialysis Plasma Concentrations of Atrial Natriuretic Peptide and Brain Natiuretic Peptide as Long-term Survival Predictors in Hemodialysis Patients : 15-year follow up study | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 血液透析 | |||||
キーワード | ||||||
主題 | 生命予後 | |||||
キーワード | ||||||
主題 | atrial natriuretic peptide (ANP) | |||||
キーワード | ||||||
主題 | brain natriuretic peptide (BNP) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | hemodialysis | |||||
キーワード | ||||||
言語 | en | |||||
主題 | survival | |||||
キーワード | ||||||
言語 | en | |||||
主題 | atrial natriuretic peptide (ANP) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | brain natriuretic peptide (BNP) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | ケツエキ トウセキ カンジャ ノ チョウキ セイメイ ヨゴ ヨソク インシ トシテノ トウセキゴ ノ ケッショウANP ト BNPノウド ノ ユウヨウセイ : 15ネンカン ノ ヨゴ チョウサ | |||||
著者 |
寺西, 恵
× 寺西, 恵× 宮下, 和久× 鈴木, 正志× 古寺, 理恵× 斉藤, 克典× 石井, 策史× 後藤, 淳郎× 西山, 敬介× 平田, 恭信× 松岡, 博昭× Teranishi, Megumi× Miyashita, Kazuhisa× Suzuki, Masashi× Hurudera, Rie× Saitou, Katsunori× Ishii, Kazuchika× Goto, Atsuo× Nishiyama, Keisuke× Hirata, Yasunobu× Matsuoka, Hiroaki |
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著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
日本赤十字社医療センター腎臓内科 | ||||||
著者所属(日) | ||||||
東京大学循環器内科 | ||||||
著者所属(日) | ||||||
獨協医科大学内科学(循環器) | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Nephrology, Department of Medicine, Japanese Red Cross Medical Center | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Cardiovascular Medicine, University of Tokyo | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Hypertension & Cardiorenal Medicine, Dokkyo Medical University School of Medicine | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 透析患者52人において心胸比を透析前に,収縮期血圧,血清アルブミン,血漿心房性ナトリウム利尿ペプチド(atrial natriuretic peptide ; ANP),脳性ナトリウム利尿ペプチド(brain natriuretic peptide ; BNP),血漿レニン活性(plasma renin activity ; PRA),血漿ノルアドレナリン(plasma noradrenaline ; PNA)濃度を透析直後に測定した.患者は上記測定の中央値で高低2群に分けてKaplan-Meier (KM)生存曲線を求め,両群の比較をLogrank法で行った.生存期間に及ぼす因子解析は測定値を説明変数,生存期間を目的変数としてCox比例hazard法で行った.いずれもp<0.05を有意と判定した. 15年間で43人が死亡し,うち40人が病死であった. KM生存曲線は高年齢群(p<0.001),高ANP群(p=0.006),高BNP群(p=0.039)で有意に生存期間が短く,心胸比,収縮期血圧,血清アルブミン, PRA, PNAにおいては高低2群間に有意差を認めなかった. Cox比例hazard法による単変量解析では年齢(p<0.001),心胸比(p=0.011), ANP (p=0.003), BNP (p=0.002)が生命予後の有意なリスク因子となり,多変量解析ではp値は年齢<0.001,心胸比0.965, ANP 0.055, BNP 0.041となり,年齢とBNPが生命予後の独立したリスク因子であった.以上より透析患者において透析直後の血漿BNP濃度は長期生命予後の独立したリスク因子であり,血漿ANP濃度もリスク因子としてBNPに次いで重要であることが示された. | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | This study was designed to clarify the clinical significance of post-dialysis plasma vasoactive substances including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), plasma renin activity (PRA) and noradrenaline (PNA) as a survival predictor in chronic hemo-dialysis (HD) patients. Immediately after HD, blood samples were collected for the measurements of serum albumin, ANP, BNP, PRA and PNA in 52 HD patients. During 15-year follow-up period 43 patients died ; 40 of diseases, 2 accident, 1 suicide. Patients were divided into two groups using the median of their age and clinical and laboratory variables. Kaplan-Meier survival analysis revealed that the groups of older age, higher plasma ANP and BNP concentration had significantly lower survival rates as compared with each counterpart (p<0.001, p=0.006, p=0.039, respectively). Univariate and multivariate Cox proportional hazard regression analyses were used to assess the potential association of their age, and clinical and laboratory variables with a survival rate. As a result of Univariate Cox hazard analysis, age, cardiothoracic ratio (CTR), and plasma ANP, and BNP concentrations had significant relationship with overall mortality (p<0.001, p=0.011, p=0.003, and p=0.002, respectively). However, stepwise multivariate analysis revealed that the significant relationship with overall mortality was shown for their age (p<0.001) and BNP (p=0.041). These results demonstrated that the post-dialysis plasma BNP concentration was an independent risk factor for long-term survival and the post-dialysis plasma ANP concentration was also an important risk factor next to the BNP concentration. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 35, 号 2, p. 71-78, 発行日 2008-07-01 |
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ISSN | ||||||
収録物識別子 | 03855023 |