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A sufficientbone window for TCS was available in 47 of 86( 71.2%) inthe PD group, 10 of 12( 86.3 %) in the MSA group, 6 of 11(54.5%) in the PSP group and 32 of 34( 94.1%) in the controlgroup. SN hyperechogenicity was scored using a fourpointscale as follows:I=none or faint, II=equivocal, III=definite, IV=marked. In accordance with previously reportedcut-off values, areas of echogenicity \u0026pound; 0.19 cm2 wereclassified as normal and areas of echogenicity \u0026pound; 0.20 cm2were classified as pathological SN hyperechogenicity.Results:The frequency of SN hyperechogenicity, assessedas III and IV scales, was significantly increased in PDpatients, and observed in 72 . 4 % of assessable SN(34/47);qui-squire;p=0.001, vs. controls). The meansize of the SN hyperechogenic area in the PD group, MSAgroup and PSP group was 0.26 cm2±0.13, 0.11 cm2±0.11and 0.23 cm2±0.04, respectively, compared with 0.07 cm2±0.06 in the control group.We have identified two clinical phenotypes, such as Richardson\u0027ssyndrome (RS) and PSP-parkinsonism (PSP-P).All of three PSP-P (100%) patients showed a pathologicalSN hyperechogenicity.Conclusion:SN hyperechogenicity was associated with asymptom of parkinsonism rather than disease specificity,and suggested a vulnerability marker of the dopaminergicneuron.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "15", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00007038859", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": 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パーキンソン関連疾患における経頭蓋超音波検査による中脳黒質の高輝度変化の検討
https://dmu.repo.nii.ac.jp/records/929
https://dmu.repo.nii.ac.jp/records/929e4486fc4-7d81-45a0-9eb2-1e32911c1557
名前 / ファイル | ライセンス | アクション |
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KJ00007038859.pdf (371.2 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
タイトル | パーキンソン関連疾患における経頭蓋超音波検査による中脳黒質の高輝度変化の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Substantia Nigra Echogenicity in Parkinsonian Disorders | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題 | transcranial sonography (TCS) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | substantianigra | |||||
キーワード | ||||||
言語 | en | |||||
主題 | Parkinson disease (PD) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | multiple systematrophy (MSA) | |||||
キーワード | ||||||
言語 | en | |||||
主題 | progressive supranuclearpalsy ( PSP) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | パーキンソン カンレン シッカン ニオケル ケイズガイ チョウオンパ ケンサ ニヨル チュウノウ コクシツ ノ コウキド ヘンカ ノ ケントウ | |||||
著者 |
岩波, 正興
× 岩波, 正興× 宮本, 智之× 宮本, 雅之× 高田, 悦雄× 平田, 幸一× Iwanami, Masaoki× Miyamoto, Tomoyuki× Miyamoto, Masayuki× Takada, Etsuo× Hirata, Koichi |
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著者所属(日) | ||||||
獨協医科大学内科学(神経) | ||||||
著者所属(日) | ||||||
獨協医科大学内科学(神経) | ||||||
著者所属(日) | ||||||
獨協医科大学内科学(神経) | ||||||
著者所属(日) | ||||||
獨協医科大学病院超音波センター | ||||||
著者所属(日) | ||||||
獨協医科大学内科学(神経) | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Neurology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Neurology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Neurology, Dokkyo Medical University | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Sonography, Dokkyo Medical University Hospital | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Neurology, Dokkyo Medical University | ||||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 目 的:パーキンソン病 (Parkinson disease:PD),多系統萎縮症 (multiple system atrophy:MSA),進行性核上性麻痺 (progressive supranuclear palsy:PSP) の患者において経頭蓋超音波検査 (transcranial sonography:TCS) よる中脳黒質の高輝度変化を検討した.方 法:パーキンソン関連疾患連続110 例 (PD 86 例,MSA 12 例,PSP 12 例) と健常者34 例に対しTCSを施行した.中脳黒質を観察しえたPD 47 例,MSA 10 例,PSP 6 例,健常者32 例を解析対象として中脳黒質高輝度所見を評価した.定性評価は高輝度の程度によって視察的にI:none or faint,II:equivocal,III:definite,IV:marked の4 段階に分類した.定量評価は中脳黒質で高輝度変化の面積が0.20 cm2 以上のとき,病的な黒質高輝度変化と定義した.結 果:定性評価では,高輝度範囲が視察的に病的と判定されるIII+IVの割合は,PD 72.4%,MSA 10.0%,PSP 66.7%,健常者3.1%であった.定量評価では,PD 63.8%,MSA 20.0%,PSP 66.7%,健常者9.4%で病的な高輝度変化をみとめた.PD,PSP で病的な高輝度変化の割合が多かった.PSP をPSP-parkinsonism( PSPP)とRichardson's syndrome の2 群に分けた場合,前者では病的な高輝度変化を3 例中3 例 (100%), 後者では3 例中1 例( 33.3%) に認められ,PSP-P で割合が高かった.MSA では10 例中2 例( 20%) に病的な高輝度を認め,いずれもパーキンソン病型の多系統萎縮症であった.結 論:パーキンソン関連疾患における病的な中脳黒質高輝度変化は,疾患特異性というよりも,パーキンソニズムの症候と関連し,ドパミン神経細胞の脆弱性を示す所見と推察された. | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Objective:We investigated substantia nigra (SN) hyperechogenicitydetermined by transcranial sonography(TCS) to detect abnormalities, and compare findings withthose from Parkinson disease (PD), multiple system atrophy(MSA), progressive supranuclear palsy (PSP) or controlsubjects.Method:In this study, echogenicity of SN was examinedin consecutive 110 parkisonian disorders patients with PD86, MSA12, PSP 11, and 34 control subjects. A sufficientbone window for TCS was available in 47 of 86( 71.2%) inthe PD group, 10 of 12( 86.3 %) in the MSA group, 6 of 11(54.5%) in the PSP group and 32 of 34( 94.1%) in the controlgroup. SN hyperechogenicity was scored using a fourpointscale as follows:I=none or faint, II=equivocal, III=definite, IV=marked. In accordance with previously reportedcut-off values, areas of echogenicity £ 0.19 cm2 wereclassified as normal and areas of echogenicity £ 0.20 cm2were classified as pathological SN hyperechogenicity.Results:The frequency of SN hyperechogenicity, assessedas III and IV scales, was significantly increased in PDpatients, and observed in 72 . 4 % of assessable SN(34/47);qui-squire;p=0.001, vs. controls). The meansize of the SN hyperechogenic area in the PD group, MSAgroup and PSP group was 0.26 cm2±0.13, 0.11 cm2±0.11and 0.23 cm2±0.04, respectively, compared with 0.07 cm2±0.06 in the control group.We have identified two clinical phenotypes, such as Richardson'ssyndrome (RS) and PSP-parkinsonism (PSP-P).All of three PSP-P (100%) patients showed a pathologicalSN hyperechogenicity.Conclusion:SN hyperechogenicity was associated with asymptom of parkinsonism rather than disease specificity,and suggested a vulnerability marker of the dopaminergicneuron. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 38, 号 1, p. 103-109, 発行日 2011-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |