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Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia
https://dmu.repo.nii.ac.jp/records/997
https://dmu.repo.nii.ac.jp/records/9973ee5d421-6830-4827-bc6b-acc6c849df07
名前 / ファイル | ライセンス | アクション |
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KJ00007845699.pdf (192.0 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題 | DNA methyltransferase | |||||
キーワード | ||||||
言語 | en | |||||
主題 | surveillance | |||||
キーワード | ||||||
言語 | en | |||||
主題 | ulcerative colitis-associated neoplasia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
雑誌書誌ID | ||||||
収録物識別子 | AA00629581 | |||||
論文名よみ | ||||||
タイトル | Diagnostic Validity of DNMT-1 and 3b Immunoreactivity in Non-neoplastic Epithelium of UC Patients with and Without Neoplasia | |||||
著者 |
Tanaka, Hiroyuki
× Tanaka, Hiroyuki× Ichikawa, Kazuhito× Fujimori, Takahiro× Ohtake, Shinichiro× Yasuda, Yoshikazu |
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著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine, Department of Surgery, Jichi Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Surgery, Jichi Medical University School of Medicine | ||||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | It is important to improve the efficacy of surveillance in UC patients with neoplasia.In the present study, we assessed the cut-off value of expression of DNMT-1 and DNMT-3b expression in the non-neoplastic rectal epithelium of patients with long-standing and extensive UC. Sixty patients with long-standing and extensive UC participated in this study( 30 with colorectal neoplasia and 30 without). Immunohistochemical analysis was performed to determine the expression of DNMT-1 and 3b in non-neoplasticrectal epithelium of UC patients without neoplasia, and in non-neoplastic rectal epithelium of UC patients with neoplasia. The level of immunoreactive DNMT-1 and DNMT-3b expression was determined as the percentage of positive cells relative to the total number of cells counted under high power magnification.DNMT-1 and 3b expression in non-neoplastic rectal epithelium of UC patients with neoplasia (0.57, range0.53-0.63)(0.32, range 0.18-0.67) was higher than in the non-neoplastic epithelium of UC patients without neoplasia (0.41, range 0.25-0.54, P=.001)(0.0, range 0.0-0.13, P<.001). ROC curve analysis confirmed0.53 and 0.07 as the best DNMT-1 and DNMT-3b cut-off values for identifying individuals at increased risk of neoplasia( area under the curve=0.798 and 0.842, respectively). The cut-off value for DNMT-1 andDNMT-3b expression in non-neoplastic rectal epithelium is therefore an efficient predictor for the increased risk of UC-associated neoplasia. | |||||
書誌情報 |
Dokkyo journal of medical sciences 巻 39, 号 1, p. 29-35, 発行日 2012-03-25 |
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ISSN | ||||||
収録物識別子 | 03855023 |