2026-03-15T17:36:14Z https://dmu.repo.nii.ac.jp/oai

oai:dmu.repo.nii.ac.jp:02000177 2024-04-03T04:27:35Z 223:1706758590590

Comparison of the Therapeutic Effects on the Renal and Life Prognosis in ANCA-associated Nephritis Yokoyama, Shohei Tojo, Akihiro open access ANCA plasma exchange steroid cyclophosphamide rituximab ANCA-associated rapidly progressive glomerulonephritis has been treated with steroid pulse therapy (mPSL pulse), cyclophosphamide pulse therapy (IVCY), rituximab (RTX), and plasma exchange (PE), but the differences in renal and life outcomes are not fully understood. To determine the long-term prognostic impact of plasma exchange in ANCA-associated rapidly progressive glomerulonephritis, we conducted a retrospective observational study with stratification by treatment modality to determine the prognostic impact of plasma exchange in ANCA-associated rapidly progressive glomerulonephritis. Eighty patients with ANCA-associated glomerulonephritis who underwent renal biopsy at our hospital were divided into 5 groups, and the renal and life prognosis were evaluated. IVCY and RTX significantly improved renal survival compared with steroid therapy and PE. PE and PSL oral groups did not improve renal prognosis, but survived without death during the observation period. PE is introduced in patients requiring hemodialysis at biopsy to rapidly reduce ANCA levels with favorable life prognosis. Dokkyo Medical Society 2023-12-25 eng journal article VoR https://dmu.repo.nii.ac.jp/records/2000177 https://doi.org/10.51040/dkmj.2023-006 AA12941861 2436-522X Dokkyo Medical Journal 2 4 281 288 https://dmu.repo.nii.ac.jp/record/2000177/files/DKMJ-2-4-4.pdf application/pdf 645 KB 2024-02-09