2026-03-13T23:06:26Z https://dmu.repo.nii.ac.jp/oai

oai:dmu.repo.nii.ac.jp:00000422 2023-06-20T16:20:19Z 81:37

Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma Masuda, Hiroyuki Manaka, Takako Toda, Masao Sugiyama, Kumiya Sagara, Hironori bronchial asthma mast cell amphiregulin goblet cell airway remodeling Abbreviations used EGF: epidermal growth factor MUC: mucin OVA: ovalbumin Th2: Type 2 helper T Mast cells play important roles in both acute-and late-phase allergic reactions mediated by IgE, such as those in bronchial asthma. Remodeling of the airway wall may contribute to the development of chronic refractory asthma; effective treatment for remodeling is currently lacking. Tryptase released by degranulated mast cells may participate in airway remodeling by stimulating the proliferation of airway smooth-muscle cells and fibroblasts and promoting the production of extracellular matrix. We found that continued antigen challenge produced time-dependent increases in the number of goblet cells, which are essential for sputum production, as well as the number of mast cells. Furthermore, the expression of amphiregulin released from mast cells was up-regulated by after ovalbumin challenges in mice. The number of amphiregulin-positive cells positively correlated with the degree of goblet-cell hyperplasia. Our results suggest that mast cells also play a key role in airway remodeling. 原著 Original journal article 2006-03-25 application/pdf Dokkyo journal of medical sciences 1 33 43 53 AA00629581 03855023 https://dmu.repo.nii.ac.jp/record/422/files/KJ00004451271.pdf https://dmu.repo.nii.ac.jp/records/422 eng