@article{oai:dmu.repo.nii.ac.jp:00001001,
 author = {城守, 美香 and 佐々木, 忠昭 and 岩瀬, 博建 and 今井, 裕 and Shiromori, Mika and Sasaki, Tadaaki and Iwase, Hirotate and Imai, Yutaka},
 issue = {1},
 journal = {Dokkyo journal of medical sciences},
 month = {Mar},
 note = {われわれは口腔扁平上皮癌の浸潤様式に対してはじめて三次元解析による検討を行ない,その有用性について報告してきた.今回は,癌の浸潤・転移において重要な役割を担う細胞外マトリックス分解酵素のうち,Matrix metalloproteinase-2 (MMP-2),MMP-9 およびMembrane type 1 matrix metalloproteinase(MT1-MMP)の発現と三次元解析による浸潤様式との関係について検討を行ったので報告する.対象は獨協医科大学病院口腔外科で加療した口腔扁平上皮癌一次症例175 例のうち,三次元解析が可能であった根治的手術症例31 例を用いた.MMP-2,MMP-9 およびMT1-MMP のそれぞれの発現陽性率は38.7%,67.7%,100%であった.非連続型は連続型に比較し,MMPs の発現頻度は高く,また発現部位は腫瘍細胞だけでなく,間質の細胞にも発現していた.非連続型はMMPs が単独で,あるいは相互に作用しあい,び慢性に浸潤することが示唆された.今回の検討により,MMPs の発現と三次元解析による浸潤様式は密接に関連し,両者とも口腔癌の治療法の決定や予後予測に有用であることが示された., We studied the mode of invasion of oral squamous cell carcinoma( OSCC) by three-dimensional( 3-D) analysis for the first time and reported its clinical usefulness. The purpose of this study is to discuss the relationship between the expression of matrix metalloproteinase (MMP)-2, MMP-9and membrane type 1-metalloproteinase( MT1-MMP) and the mode of invasion of OSCC by 3-D analysis. In this present31 of 175 patients with OSCC treated with curative surgery at first were able to be examined. The expression ofMMP-2, MMP-9 and MT1-MMP was examined by immunohistochemical techniques. The rate of MMP-2 expressionwas 38.7%, MMP-9 67.7 % and MT1-MMP 100 % . The rates of the expression of MMPs were significantly higher in discontinuous type than in continuous type. The positive expression of MMPs were detected not only in tumor cells but also in stromal cells in discontinuous type. These results indicate that MMPs contribute to the diffused invasion of OSCC with discontinuous type independently or mutually.In conclusion, the mode of invasion of OSCC by 3-Danalysis is closely related with the expression of MMPs and they can be useful to planning therapeutic strategy and predicting prognosis of the patient with OSCC., 原著, Original},
 pages = {67--75},
 title = {三次元解析による口腔扁平上皮癌の浸潤様式とMMP-2,MMP-9 およびMT1-MMP の発現に関する研究},
 volume = {39},
 year = {2012},
 yomi = {シロモリ, ミカ and ササキ, タダアキ and イワセ, ヒロタテ and イマイ, ユタカ}
}