{"created":"2023-06-20T14:25:47.042467+00:00","id":1007,"links":{},"metadata":{"_buckets":{"deposit":"dc56d55a-39d9-4401-9265-337802f373e4"},"_deposit":{"created_by":3,"id":"1007","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1007"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001007","sets":["81:61"]},"author_link":["4702"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T11","bibliographicPageStart":"T1","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ケモカインSDF-1 とその受容体であるCXCR4 による ケモカインシステムは,癌の転移ならびに細胞増殖に関与すると報告されており,多臓器において研究がなされているが,その発現と臨床的意義については,一定の見解が得られていない.今回われわれは,舌扁平上皮癌におけるSDF-1/CXCR4 の発現と臨床病理学的因子(年齢,性別, pT, pN, pStage, 分化度, Y-K 分類,5 年累積生存率)との関係について検討をしたので報告する.対象は,当科にて手術療法を施行した舌扁平上皮癌一次症例53 例で,未治療生検組織を用い,リアルタイムRT-PCR による遺伝子発現および免疫組織化学染色法を用い発現検索を行った.その結果,SDF-1遺伝子発現例に頸部リンパ節転移が有意に多く, 5 年累積生存率においては,SDF-1 ならびにCXCR4 遺伝子が両者共に発現した症例は,SDF-1 とCXCR4 遺伝子両者共に発現しなかった症例と比べ,有意に生存率が不良であった.しかしながら,それ以外の因子では,遺伝子検索ならびに免疫組織化学染色による検討のいずれにおいても,SDF-1 とCXCR4 の発現と臨床病理学的因子との関連は認めなかった.本研究の結果より,SDF-1 遺伝子の発現は,舌扁平上皮癌のリンパ節転移と関連し,SDF-1/CXCR4 の発現は,予後予測因子となりえることが示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学口腔外科学"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ゼツ ヘンペイ ジョウヒ ガン ニオケル SDF-1/CXCR4 ハツゲン ト リンショウ ビョウリテキ インシ トノ カンレン ニ ツイテ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中津川, 周生"},{"creatorName":"ナカツガワ, チカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4702","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00007851359.pdf","filesize":[{"value":"850.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00007851359.pdf","url":"https://dmu.repo.nii.ac.jp/record/1007/files/KJ00007851359.pdf"},"version_id":"8fecd44f-c7b8-43fa-8f5b-e832402b06b3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔癌","subitem_subject_scheme":"Other"},{"subitem_subject":"頸部リンパ節転移","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"SDF-1","subitem_subject_scheme":"Other"},{"subitem_subject":"CXCR4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"舌扁平上皮癌におけるSDF-1/CXCR4 発現と臨床病理的因子との関連について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"舌扁平上皮癌におけるSDF-1/CXCR4 発現と臨床病理的因子との関連について"}]},"item_type_id":"2","owner":"3","path":["61"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"1007","relation_version_is_last":true,"title":["舌扁平上皮癌におけるSDF-1/CXCR4 発現と臨床病理的因子との関連について"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:03:54.202325+00:00"}