@article{oai:dmu.repo.nii.ac.jp:00001081,
 author = {Maruoka, Takashi and Tomita, Shigeki and Ichikawa, Kazuhito and Kojima, Masaru and Hakata, Yuko and Imai, Yutaka and Imura, Johji and Fujimori, Takahiro},
 issue = {1},
 journal = {Dokkyo journal of medical sciences},
 month = {Mar},
 note = {Objective:Oral lichen planus( OLP) is a chronic inflammatory oral mucosal disease of unknown etiology.Due to similar histological features of OLP with other oral diseases. IgG4-related disease has been identified,but whether or not there are organ-specific characteristics related to the etiologic factors is still unknown.In the present study, we investigated the significance of IgG4-positive plasma cells as a marker for OLP.Methods:Biopsy specimens from 63 patients with white papules, erythema and erosive mucosa in theoral cavity were obtained. The lesions were evaluated for inflammatory cell spreading pattern classified ashorizontal superficial type and/or expanding type(s), for lymphoid-plasma cell markers (CD3, CD20,CD79a), Immunoglobulin G( IgG, IgG4) immunoreactivity, and for monoclonality.Results:In the horizontal superficial type with only CD3-positive lymphocytic inflammatory cells wererestricted to the epithelial layer of connective tissue without presence of IgG4-positive plasma cells. Lesionswere further demonstrated to contain CD3-, CD20- and CD79a-positive lympho-plasma cells with focal cytoplasmicIgG4 expression. However, in IgG4-rich cases, there were no monoclonality. The inflammatorycell spreading pattern differed significantly between the horizontal superficial type with only CD3-positivelymphoid cells and expanding types, and was significantly associated with IgG4-positive plasma cells.Conclusions:Detection of IgG4-positive plasma cells and inflammatory cell spreading pattern may beuseful for differential diagnosis and selection of treatable cases in OLP., Original},
 pages = {17--25},
 title = {IgG4-positive Plasmocytosis of Inflammatory Cell Spreading Pattern Revealed to Differentiation in Classic Oral Lichen Planus},
 volume = {40},
 year = {2013}
}