| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
IL-33 and RANTES( Regulated on Activation, Normal T Cell Expressed and Secreted) in BAL Fluid in Asthma Patients Without Cigarette Smoking |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
BAL fluid |
| キーワード |
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言語 |
en |
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主題 |
IL-33 |
| キーワード |
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言語 |
en |
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主題 |
RANTES |
| キーワード |
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言語 |
en |
|
主題 |
asthma |
| キーワード |
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|
言語 |
en |
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主題 |
smoker |
| キーワード |
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言語 |
en |
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主題 |
atopy |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
IL-33 and RANTES( Regulated on Activation, Normal T Cell Expressed and Secreted) in BAL Fluid in Asthma Patients Without Cigarette Smoking |
| 著者 |
Tatewaki, Masamitsu
Hirata, Hirokuni
Fukushima, Fumiya
Fukushima, Yasutsugu
Sugiyama, Kumiya
Fukuda, Takeshi
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| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Background:Inflammatory cytokines and chemokines have been reported to play important roles in thepathogenesis of bronchial asthma. However, no criteria for the classification of `smoker' and `atopic' in bronchialasthma have been defined. In this study, we compared the levels of several cytokines found in thebronchoalveolar lavage( BAL) fluid of patients classified as having bronchial asthma.Methods:Cell subpopulations in BAL fluid were counted. BAL fluid levels of interleukin( IL)-4, -5, -13,-17, and -33 and RANTES (regulated on activation, normal T cell expressed and secreted were measuredusing a bead suspension array in 36 asthma patients (13 males, 23 females;mean age, 39.5±92.8 years)who were non-smokers, 18 asthma patients( 11 males, 7 females;mean age, 30.7±2.7 years) who were exor current smokers( Brinkman index( BI):1−399), and 10 asthma patients( 9 males, 1 female;mean age,50.2±5.5 years) who were current heavy smokers( BI:≥ 400). Relationships were assessed by Spearman'srank correlation analysis.Results:The number of lymphocytes in BAL cell subpopulations of non-smokers( 25±7×103/ml) weresignificantly (p<0.05) higher than those of heavy smokers (12±3×103 /ml). The number of neutrophilswas significantly( p<0.05) higher in heavy smokers( 18±9×103/ml) than in non-smokers( 4±2×103/ml).Levels of IL-33 and RANTES were significantly (P<0.05) higher in non-smokers (26.1±7.3 pg/ml and42.8±10.3 pg/ml, respectively) than in heavy smokers (13.7±4.5 pg/ml and 27.4±5.4 pg/ml, respectively).In addition, the levels of IL-33 and RANTES in non-smokers were significantly( P<0.05) higher in atopicasthma patients (33.0±9.8 pg/ml and 47.8±14.0 pg/ml, respectively) than in non-atopic asthma patients(9.1±3.8 pg/ml and 29.5±7.8 pg/ml, respectively). A good correlation was noted between RANTES andlymphocytes (R=0.365, P<0.05) or IL-33 (R=0.561, P<0.05) in atopic asthma patients who were nonsmokers.Conclusions:Differences in the cell types of BAL fluid, as well as in the levels of IL-33 and RANTES inasthma patients with or without smoking, might reflect pathogenesis. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 40,
号 1,
p. 27-37,
発行日 2013-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00008416399.pdf (1.3 MB)
