{"created":"2023-06-20T14:25:50.852638+00:00","id":1083,"links":{},"metadata":{"_buckets":{"deposit":"4d1953ab-5f51-4c5d-856f-822f9ad2fe54"},"_deposit":{"created_by":3,"id":"1083","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1083"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001083","sets":["81:65"]},"author_link":["5083","5084","5080","5085","5081","5086","5087","5088","5082"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"46","bibliographicPageStart":"39","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Background and Objective:Chronic interstitial pneumonia (IP) might include chronic hypersensitivity pneumonitis (HP) and chronic bird-related hypersensitivity pneumonitis (BRHP). A specific antigen is difficult to identify in these diseases, and such evidence would provide important clues suggesting a diagnosis of HP. In this study, we used an ImmunoCAP analysis system to measure specific IgG antibodies against pigeons and budgerigars in the sera of patients with IP and investigated the involvement of bird-related IgG antibodies in IP.Methods:The study group comprised 22 patients with idiopathic pulmonary fibrosis (IPF), 8 with chronic IP, 7 with subacute HP, 7 with chronic HP, and 10 with control diseases. All cases were diagnosed from 2000 through 2011 at the Institute of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University. Clinical features, results of laboratory examinations, and levels of serum IgG antibodies against pigeons and budgerigars were compared.Results:There were no significant differences among the disease groups in C-reactive protein, leukocyte count, lactate dehydrogenase, and the results of blood gas analysis. KL-6 and surfactant protein D were significantly higher in subacute HP and chronic HP. The levels of anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies in each disease group were respectively as follows:IPF, 11.02±5.97&#8200;mg/l, 5.03±3.97&#8200;mg/l;chronic IP, 10.04±8.55&#8200;mg/l, 3.30±1.47&#8200;mg/l;subacute HP, 14.39±9.13&#8200;mg/l, 7.96±6.47&#8200;mg/l;chronic HP, 24.97±16.19&#8200;mg/l, 11.50±13.80&#8200;mg/l;and control diseases, 8.66±3.15&#8200;mg/l, 3.77±1.05&#8200;mg/l. The mean levels of anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies were significantly higher in chronic HP. There was a positive correlation between anti-pigeon IgG antibodies and anti-budgerigar IgG antibodies (R2 = 0.715, p<0.001). Conclusions:In patients with clinically diagnosed chronic HP, high levels of anti-pigeon IgG antibodies or anti-budgerigar IgG antibodies were confirmed using an ImmunoCAP analysis system. In general, HP (especially chronic HP) is difficult to diagnose definitively, and this analysis system is expected to facilitate diagnosis.","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"ENG","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mashio, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Yasutsugu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oomi, Fumito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umetsu, Takafumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Naruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Naoya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirata, Hirokuni","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugiyama, Kumiya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00008416759.pdf","filesize":[{"value":"381.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00008416759.pdf","url":"https://dmu.repo.nii.ac.jp/record/1083/files/KJ00008416759.pdf"},"version_id":"b54a4877-fb8b-475f-a1db-23f219948d2b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"idiopathic pulmonary fibrosis","subitem_subject_language":"en"},{"subitem_subject":"chronic interstitial pneumonia","subitem_subject_language":"en"},{"subitem_subject":"chronic hypersensitivity pneumonitis","subitem_subject_language":"en"},{"subitem_subject":"bird-related hypersensitivity pneumonitis","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["65"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"1083","relation_version_is_last":true,"title":["Involvement of Bird-related IgG Antibodies in Interstitial Pneumonia"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T15:56:12.536059+00:00"}