{"created":"2023-06-20T14:25:51.318731+00:00","id":1090,"links":{},"metadata":{"_buckets":{"deposit":"c2a66a0a-324e-4ee4-af4b-83734d59058c"},"_deposit":{"created_by":3,"id":"1090","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1090"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001090","sets":["81:65"]},"author_link":["5150"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T22","bibliographicPageStart":"T13","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ヒト循環血中の樹状細胞( DC)にはmyeloid DC( mDC)とplasmacytoid DC( pDC) の2つの主要なサブセットが存在し,mDC は,Th1 を誘導するmDC1 と,Th2 を誘導するmDC2 に分けられる.本研究では,Th1疾患であるサルコイドーシス( サ症)( n=30)とTh2疾患であるアトピー性疾患( n=23)における末梢血DC サブセットを,健常人 (n=23)と比較して検討した.フローサイトメトリーを用いて末梢血中のmDC(CD11c+),pDC( CD123+),mDC1( CD1a+),mDC2( CD141+)のサブセット解析を行った.サ症群では総DC, mDC の数が有意に低下していた.mDC/pDC 比は3 群間で差がなかった.CD1a+mDC は,サ症群では対照群と差がなかったが,アトピー群ではCD1a+mDC の減少,CD1a−mDC の増加を認め,CD1a+/CD1a−mDC比は小さかった.CD141+mDC はアトピー群で有意に増加していたが,CD141−mDC 数は3 群間で有意差はなかった.CD141−/CD141+mDC 比はアトピー群で有意に低値であった.アトピー群では,CD1a+mDC の減少とCD141+mDC の増加を認め,末梢血中DC の動態がTh2 への偏倚を反映するものと考えられた.サ症では,DC 数は減少し,その動態からはTh1/Th2 の偏倚は明確でなく,肺などの病変局所に集積したDC を用いた解析が必要と考えられた.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Th1/Th2 カンレン シッカン ニオケル マッショウ ケツ ジュジョウ サイボウ サブセット ノ カイセキ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, ゆめ子"},{"creatorName":"ハヤシ, ユメコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00008419740.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00008419740.pdf","url":"https://dmu.repo.nii.ac.jp/record/1090/files/KJ00008419740.pdf"},"version_id":"ab40aa69-98f1-4815-bc0a-615d8473dde5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"樹状細胞"},{"subitem_subject":"ヒト末梢血"},{"subitem_subject":"myeloid DC"},{"subitem_subject":"CD1a"},{"subitem_subject":"CD141"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析"}]},"item_type_id":"2","owner":"3","path":["65"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"1090","relation_version_is_last":true,"title":["Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T15:56:21.852475+00:00"}