@article{oai:dmu.repo.nii.ac.jp:00001147,
 author = {鈴木, 國弘 and 青木, 千枝 and 飯嶋, 寿江 and 田中, 精一 and 二井谷, 舞 and 城島, 輝雄 and 麻生, 好正 and Suzuki, Kunihiro and Aoki, Chie and Iijima, Toshie and Tanaka, Seiichi and Niitani, Mai and Jojima, Teruo and Aso, Yoshimasa},
 issue = {3},
 journal = {Dokkyo journal of medical sciences},
 month = {Oct},
 note = {要 旨 【目的】血管内皮機能障害は動脈硬化発症の端緒であり,糖尿病患者の血管障害を評価する上で非常に有用な生理学的機能検査である.そこで,実際の糖尿病診療をうけている患者の内皮機能を評価し,各種パラメータが与える影響を検討した.【方法】獨協医科大学内分泌代謝内科に通院している合併症のない2 型糖尿病患者に対して,臨床研究に同意した234名( 男性:133名,女性:101名)を対象として, 血管内皮機能を測定し,血糖値,血圧,脂質,喫煙歴,糖尿病罹患歴,Body mass index に対する相関を検討した.【結果】血糖コントロール(HbA1c),( 収縮期)血圧, 脂質(TG, LDL, non-HDL)に血管内皮機能は相関を認め,また糖尿病罹患歴にも相関を認めた.【結論】血管内皮機能検査で動脈硬化をより早期に拾い上げ,相関した因子を厳重に管理することで,糖尿病患者の動脈硬化性疾患の発症・進展阻止に十分な効果が期待できると考えられた., Background:The endothelium plays a major role in the regulation ofvascular tone. Endothelial dysfunction precedes apparentatherosclerosis in human. Type 2 diabetes mellitus(T2DM) is one of the most risk factors for arterioscleroticvascular disease, primarily, as the result of adverse changesin arteries. Therefore, identifying the factors related to impairedendothelial- dependent dilation with T2DM is crucialfor the purpose of prevention and/or treatment endothelialdysfunction.Objective:The aim of this study was to examine relevant factors associatedwith endothelial dysfunction in T2DM. In a total of234 diabetes patients, we assessed endothelial function byflow-mediated dilation and analyzed relevant factors effectedon endothelial function.Methods:We enrolled 234 T2DM patients attending Dokkyo MedicalUniversity Hospital( April from 2008 to February 2012).There were no changes in medications on hypertension, diabetes,and dyslipidemia during the previous 3 months. Thevascular response to reactive hyperemia in the brachial arterywas used for assessment of endothelial function(Flow-mediated dilation:FMD).Results:In this study, HbA1c, systolic blood pressure, LDL-cholesterol,Triglycerides, and duration of diabetes were negativelyassociated with % FMD by simple linear regressionanalysis. Furthermore, multivariate analysis revealed thatHbA1c, LDL-cholesterol, and duration of diabetes were alsoindependent predictors of the endothelial dysfunction.Conclusion:Our data showed that the tight management of relevantfactors related to impaired endothelial function in T2DM,might improve endothelium-dependent dilatation, suggestinga potential reduction in overall arteriosclerotic vasculardisease., 原著, Original},
 pages = {169--174},
 title = {2 型糖尿病患者の血管内皮機能評価およびその関連因子の検討},
 volume = {40},
 year = {2013},
 yomi = {スズキ, クニヒロ and アオキ, チエ and イイジマ, トシエ and タナカ, セイイチ and ニタニ, マイ and ジョウジマ, テルオ and アソウ, ヨシマサ}
}