| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway remodeling |
| キーワード |
|
|
言語 |
en |
|
主題 |
bronchial asthma |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway smooth muscle |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway hyperresponsiveness |
| キーワード |
|
|
言語 |
en |
|
主題 |
airway hyperresponsiveness |
| キーワード |
|
|
言語 |
en |
|
主題 |
corticosteroids |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
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タイトル |
Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids |
| 著者 |
Hiyama, Takako
Kamikawa, Yuichiro
Ota, Mayumi
Nakano, Yasuhiro
Sagara, Hironori
|
| 著者所属(英) |
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pharmacology, Dokkyo University School of Medicine |
| 著者所属(英) |
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Airway remodeling in bronchial asthma occurs as a result of continuance or repetition of eosinophilic airway inflammation. It has the potential to affect airway responsiveness to nonspecific stimuli and the pharmacological properties of airway smooth muscle, but the direct evidence of this is sparse. It is also unknown whether corticosteroids can prevent the development of airway remodeling. To assess these questions, we made a guinea pig model of chronic asthma that consistently showed airway remodeling and analyzed it not only pathologically but also physiologically and pharmacologically. The effects of the corticosteroid treatment on the development of airway remodeling were also examined. Guinea pigs were sensitized by repeated exposure to aerosolized ovalbumin (OVA) and challenged once a week with the inhalation of the same antigen over a 24 week period. Five days after the last antigen challenge, airway responsiveness to inhaled histamine was determined, the animals were then sacrificed, and the lungs and tracheae were removed. Airway responsiveness in this model was significantly increased compared with that in control animals that were challenged with saline. Pharmacological experiments using extracted tracheal and bronchial smooth muscle revealed that carbamylcholine-induced tracheal muscle contraction was significantly greater in the remodeling model than in the control animals. In the contrast, isoproterenol-induced tracheal muscle relaxation was significantly lower in the remodeling model than in the control animals. The treatment with intraperitoneal injection of 20 mg/kg or 40 mg/kg triamcinolone before each OVA challenge significantly blocked the development of airway remodeling, an increase in airway hyperresponsiveness and changes in pharmacological properties of airway smooth muscle. Thus, the present results indicate that airway remodeling enhances an airway responsiveness to nonspecific stimuli and alters contractile and relaxing responses of airway smooth muscle, and these changes can be prevented by corticosteroids together with structural changes of airways. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 30,
号 1,
p. 29-38,
発行日 2003-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00000010446.pdf (1.1 MB)
