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  1. Dokkyo Journal of Medical Sciences
  2. 30(1) 2003

Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids

https://dmu.repo.nii.ac.jp/records/115
https://dmu.repo.nii.ac.jp/records/115
94e49140-4f9b-49d9-82a7-4673be1695c5
名前 / ファイル ライセンス アクション
KJ00000010446.pdf KJ00000010446.pdf (1.1 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
言語 en
タイトル Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids
言語
言語 eng
キーワード
言語 en
主題 airway remodeling
キーワード
言語 en
主題 bronchial asthma
キーワード
言語 en
主題 airway smooth muscle
キーワード
言語 en
主題 airway hyperresponsiveness
キーワード
言語 en
主題 airway hyperresponsiveness
キーワード
言語 en
主題 corticosteroids
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Airway Remodeling in a Guinea Pig Model of Chronic Asthma : Its Influence on Airway Responsiveness and Pharmacological Properties of Airway Smooth Muscle, and Its Prevention by Corticosteroids
著者 Hiyama, Takako

× Hiyama, Takako

WEKO 314

en Hiyama, Takako

Search repository
Kamikawa, Yuichiro

× Kamikawa, Yuichiro

WEKO 315

en Kamikawa, Yuichiro

Search repository
Ota, Mayumi

× Ota, Mayumi

WEKO 316

en Ota, Mayumi

Search repository
Nakano, Yasuhiro

× Nakano, Yasuhiro

WEKO 317

en Nakano, Yasuhiro

Search repository
Sagara, Hironori

× Sagara, Hironori

WEKO 318

en Sagara, Hironori

Search repository
著者所属(英)
en
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pharmacology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
著者所属(英)
en
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Airway remodeling in bronchial asthma occurs as a result of continuance or repetition of eosinophilic airway inflammation. It has the potential to affect airway responsiveness to nonspecific stimuli and the pharmacological properties of airway smooth muscle, but the direct evidence of this is sparse. It is also unknown whether corticosteroids can prevent the development of airway remodeling. To assess these questions, we made a guinea pig model of chronic asthma that consistently showed airway remodeling and analyzed it not only pathologically but also physiologically and pharmacologically. The effects of the corticosteroid treatment on the development of airway remodeling were also examined. Guinea pigs were sensitized by repeated exposure to aerosolized ovalbumin (OVA) and challenged once a week with the inhalation of the same antigen over a 24 week period. Five days after the last antigen challenge, airway responsiveness to inhaled histamine was determined, the animals were then sacrificed, and the lungs and tracheae were removed. Airway responsiveness in this model was significantly increased compared with that in control animals that were challenged with saline. Pharmacological experiments using extracted tracheal and bronchial smooth muscle revealed that carbamylcholine-induced tracheal muscle contraction was significantly greater in the remodeling model than in the control animals. In the contrast, isoproterenol-induced tracheal muscle relaxation was significantly lower in the remodeling model than in the control animals. The treatment with intraperitoneal injection of 20 mg/kg or 40 mg/kg triamcinolone before each OVA challenge significantly blocked the development of airway remodeling, an increase in airway hyperresponsiveness and changes in pharmacological properties of airway smooth muscle. Thus, the present results indicate that airway remodeling enhances an airway responsiveness to nonspecific stimuli and alters contractile and relaxing responses of airway smooth muscle, and these changes can be prevented by corticosteroids together with structural changes of airways.
書誌情報 Dokkyo journal of medical sciences

巻 30, 号 1, p. 29-38, 発行日 2003-03-25
ISSN
収録物識別子 03855023
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