@article{oai:dmu.repo.nii.ac.jp:00001173,
 author = {林, 雅綾 and 林, 雅敏 and 坂本, 秀一 and Hayashi, Masaaya and Hayashi, Masatoshi and Sakamoto, Shuichi},
 issue = {1},
 journal = {Dokkyo journal of medical sciences},
 month = {Mar},
 note = {当院に通院し,informed consent を得た妊婦37 人を対象として正常妊娠を維持した妊婦(N 群)19人と,妊娠高血圧症候群をきたした妊婦(P 群)18 人について,分娩時母体血および分娩直後の臍帯血を採取しそれぞれのM-CSF とβ -NGF を測定した.M-CSF とβ -NGF 濃度はいずれもP 群において有意に高値を示し,妊娠高血圧症候群とこれらサイトカイン上昇との関連が示唆された.M-CSF は主として強力な造血系細胞の調節因子である.これに加え,妊娠中の母体脱落膜,絨毛,羊膜,胎児尿などにも存在することが判明しており,絨毛の分化誘導因子となり,さらに妊娠維持に不可欠なホルモン分泌・促進にも関与していることも明らかになってきた.β -NGF は神経栄養因子(neurotrophin:NT)の一つである.NGF は特に交感神経の標的組織やシュワン細胞などの神経組織,およびその周辺で産生されるが,胎盤においてもその生物学的活性が確認されている.これら妊娠維持と密接にかかわるサイトカインが妊娠高血圧症候群の妊婦において,正常妊娠よりも高値であることが判明した.今後症例数を増やし,更に様々なサイトカインを解析することにより妊娠高血圧症候群の原因検索,発症の予測などに寄与できるものであると考える., The subjects of the present study are 37 pregnant wome carrying single fetuses, of whom 19 were women who maintained normal pregnancy (Group N) and 18 were women who had pregnancy-induced hypertension (Group P). We collected both maternal blood and umbilical cord blood from these groups at the time of childbirth and measuredM-CSF and β -NGFconcentrations in the blood.The M-CSF and β -NGF concentrations of Group P were significantly higher than Group N, suggesting that pregnancy-induced hypertension increased these cytokines.M-CSF is mainly a strong modulator of hematopoietic cells. In addition, it has been discovered that M-CSF exists in decidua, villi, amnion and fetal urine in pregnancy. M-CSF is also a differentiation-inducing factor of villi and involves in hormone secretion and stimulation, which is essential for pregnancy maintenance.Also, β -NGF is one of the neurotropic factors (neutropin). β -NGF is produced especially in the tissues of the sympathetic nervous system and in the nerve tissues ofSchwann cells, or around these types of tissues. It is confirmed that β -NGF is biologically active in the placenta.It was discovered that the types of cytokines closely related to pregnancy maintenance were higher in pregnant women with pregnancy-induced hypertension., 原著},
 pages = {63--70},
 title = {妊娠高血圧症候群の母体血および臍帯血の血清中に含まれるM-CSF およびβ-NGF の変動},
 volume = {41},
 year = {2014},
 yomi = {ハヤシ, マサアヤ and ハヤシ, マサトシ and サカモト, シユウイチ}
}