@article{oai:dmu.repo.nii.ac.jp:00001180,
 author = {増山, 裕信 and 土肥, 豊 and 上田, 善彦 and 今井, 裕 and Masuyama, Hironobu and Doi, Yutaka and Ueda, Yoshihiko and Imai, Yutaka},
 issue = {1},
 journal = {Dokkyo journal of medical sciences},
 month = {Mar},
 note = {KPNA2(Karyopherin-α 2)は,核- 細胞質間蛋白輸送因子の一つで,癌の細胞増殖ならびに転移に関与することが報告がされているが,その発現と臨床的意義については,なお不明な点が多い.今回われわれは,舌扁平上皮癌におけるKPNA2 の発現と臨床病理学的因子(年齢,性別,T stage, pN, Stage, 分化度,YK- 分類,Ki-67,5 年累積生存率)との関係について検討したので報告する.対象は,当科にて手術療法を施行した舌扁平上皮癌一次症例66 例で,未治療生検組織を用い免疫組織化学染色を行い,発現検索を行った.その結果,KPNA2 の発現は頸部リンパ節転移症例,Stage IV,低分化型,Y-K4 型ならびにKi-67L.I. 高率症例に有意に多く,5 年累積生存率では,発現例は非発現例と比べ,有意に生存率が低い結果であった.また,多変量解析の結果,KPNA2 発現は腫瘍の増殖,ならびにリンパ節転移の危険因子と考えられた.以上より,舌扁平上皮癌においても,KPNA2 発現は,リンパ節転移,腫瘍の分化,浸潤,増殖ならびに治療成績と関連し,新たな予後規定因子になり得ると思われた., Background Karyopherin- α2 (KPNA2) is a member of the importin alpha family and has recently been reported to play an important role in lymph node metastasis and tumorigenesis and tumor progression. The aim of the current study was to elucidate the clinicopathological significance of immunohistochemical expression of KPNA2 in tongue squamous cell carcinomas( SCC).Patient and Method Biopsy specimens were obtain from 66 tongue SCC patient( 43 males and 23 females) who had undergone resection at Dokkyo Medical University, Department of Oral and Maxillofacial surgery between 2003 and 2011 after obtaining their written informed consent. The age of patients ranged from 27 to 90 years with a mean of 60.5 years. KPNA2 expression was investigated by immunohistochemical in 66 tongue SCC biopsy specimens, and the association of KPNA2 expression with clinicopathologic features was also examined.Result Expression of KPNA2 in tongue SCC tissues. 30 (45.5%) cases showed positive expression of KPNA2 and 36( 54.5%) did not. Positive expression of KPNA2 showed a significant association with lymph node metastasis (P=0.005), poor differentiation (P=0.002). YK-classfication (P=0.032), Ki-67 labeling index (P<0.001). The overall survival rate of the tongue SCC patients whose tumors demonstrated positive expression of KPNA2 was significantly lower than that of the tongue SCC patients that did not( P=0.046).Conclusion KPNA2 expression suggests poor prognosis in patients with tongue SCC., 原著},
 pages = {121--128},
 title = {舌扁平上皮癌におけるKPNA2 発現の臨床的意義に関する検討},
 volume = {41},
 year = {2014},
 yomi = {マスヤマ, ヒロノブ and ドイ, ユタカ and ウエダ, ヨシヒコ and イマイ, ユタカ}
}