{"created":"2023-06-20T14:25:03.469274+00:00","id":119,"links":{},"metadata":{"_buckets":{"deposit":"070cb9a7-fc37-4910-a257-33dc16052d10"},"_deposit":{"created_by":3,"id":"119","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"119"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000119","sets":["81:25"]},"author_link":["337","338"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"70","bibliographicPageStart":"61","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"血管腔の著明な拡張を呈する形態学的特徴をもつ海綿状血管腫(CH)および静脈性血管腫(VH)の増殖様式と形態形成機序を解明するため肉芽組織型血管腫(GTTH)を対照群に,細胞増殖因子,血管新生調節因子,細胞外マトリックスについて免疫組織学的に比較検討を行った。海綿状血管腫,静脈性血管腫のKi-67は,肉芽組織型血管腫よりも低く,緩徐に増殖する腫瘍とみなされた。血管新生調節因子のうちTGF-βは海綿状血管腫および静脈性血管腫の間質層において有意に低値であり,PDGFは海綿状血管腫の間質層において有意に高値であった。TGF-βは,これら二つの腫瘍における異常な血管拡張に対し中心的な役割を果たしていることが示唆された。PDGFのスコア値の差は海綿状血管腫と静脈性血管腫の壁細胞分布の違いに関与していることが示唆された。Type III collagenは間質層において,fibronectinは内皮層において両腫瘍とも高値だった。血管新生の過程において,従来検討の少なかった線維芽細胞をはじめとする間質層の細胞の役割が重要である。","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Cavernous hemangioma (CH) as well as venous hemangioma (VH) are histologically characterized by remarkably dilated vessels. To clarify the morphogenesis in CH and VH, we performed immunohistochemical study on 17 cases of CH and 14 cases of VH. The results were compared with those also performed of granulation tissue type of hemangioma (GTTH), which is reactive proliferative lesion of the capillaries. The panel of antibodies included a cell cycle associated marker (Ki-67), six angiogenetic-factors and receptors (VEGF, PDGF, TGF-β, Ang-1, Ang-2, Tie-2), and three extracellular matrices (type III collagen [Col III], type IV collagen [Col IV] and fibronectin). The number of Ki-67 positive cells was evaluated as Ki-67 labeling index (Ki-67 LI). Evaluation of positive cells of angiogenetic-factors and receptors were scored using a four-tiered scale. The intensity of expression of extracellular matrices was also scored according to four tiered grades. Ki -67 LI in both CH and VH was significantly lower than that in GITH (p K 0.05). Among angiogenic-factors and receptors, the score of TGF-β in CH and VH was significantly lower than that in GTTH (p < 0.05). The score of PDGF in CH was significantly higher than that of GTTH. Among extracellular matrices, the score of CollII and fibronectin in both CH and VH were significantly higher than that of GTTH (p < 0.05). The low Ki-67L1 in CH and VH indicates that both CE and VH are slow-growing tumors. Moreover, overexpression of TGF-β may play a central role of abnormal dilatation in blood vessels in both CH and VH.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学整形外科学"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Orthopedic Surgery, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ヒフ,ネンマクカ ニオケル カイメンジョウ ケッカンシュ オヨビ ジョウミャクセイ ケッカンシュ ノ メンエキソシキガクテキ ケントウ : トクニ ニクガ ソシキガタ ケッカンシュ トノ ヒカク ニ オイテ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 浩史"},{"creatorName":"タナカ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"338","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00000010450.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000010450.pdf","url":"https://dmu.repo.nii.ac.jp/record/119/files/KJ00000010450.pdf"},"version_id":"6f5ab5c4-820f-4f38-88bc-f01b737e0fa5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"海綿状血管腫","subitem_subject_scheme":"Other"},{"subitem_subject":"静脈性血管腫","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外マトリックス","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet-derived endothelial growth factor(PDGF)","subitem_subject_scheme":"Other"},{"subitem_subject":"transforming growth factor beta(TGF-β)","subitem_subject_scheme":"Other"},{"subitem_subject":"cavernous hemangioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"venous hemangioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet-derived endothehal growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transforming growth factor beta","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"皮下,粘膜下における海綿状血管腫および静脈性血管腫の免疫組織学的検討 : 特に肉芽組織型血管腫との比較において","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮下,粘膜下における海綿状血管腫および静脈性血管腫の免疫組織学的検討 : 特に肉芽組織型血管腫との比較において"},{"subitem_title":"Immunohistochemical Study of Cavernous Hemangioma and Venous Hemangioma in Subcutaneous Tissue and Submucosal Tissue","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["25"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"119","relation_version_is_last":true,"title":["皮下,粘膜下における海綿状血管腫および静脈性血管腫の免疫組織学的検討 : 特に肉芽組織型血管腫との比較において"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:22:37.043602+00:00"}