{"created":"2023-06-20T14:25:59.559424+00:00","id":1236,"links":{},"metadata":{"_buckets":{"deposit":"1cd510fe-40cd-4235-b7f2-2350f53e4d22"},"_deposit":{"created_by":3,"id":"1236","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1236"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001236","sets":["81:71"]},"author_link":["6110","6111"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"229","bibliographicPageStart":"221","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"単純型熱性けいれんは良性疾患として認識されているが,その一部では長期間にわたる影響を海馬に及ぼすことが報告されている.そこで,軽度の熱性けいれんによる長期的な影響を明らかにするために,新生マウスに短時間の実験的熱性けいれんを誘発した.その後,Timm 染色により,苔状線維の異常な分岐を評価し,パッチクランプ・ホールセル法により,歯状回顆粒細胞の興奮性伝達を解析した.その結果,苔状線維の異常発芽は観察されなかったが,歯状回顆粒細胞でのグルタミン酸作動性の興奮性シナプス伝達がシナプス前性に亢進していた.この変化はsyntaxin 1A の発現低下も伴っていた.さらに海馬培養ニューロンにおいて,アンチセンスオリゴヌクレオチドによるsyntaxin 1A のノックダウンが,グルタミン酸の開口放出を増加させることを観察した.以上の結果から,軽度の実験的熱性けいれんが長期にわたり,syntaxin1A の発現変化と関連して海馬歯状回の興奮性シナプス伝達を亢進させることが示唆された.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Simple febrile seizures (FS) are generally believed to constitute a benign disease. However, previous studies report that simple FS show subtle, but long-lasting, effects in the hippocampus. We subjected neonatal mice to brief experimental FS. Using Timm staining and tight-seal wholerecordings, we examined whether such mild FS exerts long-lasting influences on mossy fiber sprouting and excitatory synaptic transmission in the dentate gyrus (DG) of the hippocampal slices. Although brief experimental FS did not induce apparent mossy fiber sprouting in the hippocampal DG, it lead to presynaptic enhancement of glutamatergic excitatory synaptic transmission in the DG. This was accompanied by down-regulation of syntaxin 1A, a member of the presynaptic SNARE proteins, in the DG. Furthermore, we observed in cultured hippocampal neurons that antisense oligodeoxynucleotide-induced knock-down of syntaxin 1A increased the probability of synaptic release of glutamate. These findings suggest that simple FS during the neonatal period may exert a trace of an augmentative effect on excitatory synaptic transmission in the DG in adulthood.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学生理学(生体情報)"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department Of Physiology And Biological Information, Dokkyo Medical University School Of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"マウス カイバ シジョウカイ ニ オケル タン ジカン ノ ジッケン テキ ネッセイ ケイレン ニ ヨル コウフン セイ シナプス デンタツ エ ノ チョウキ テキ エイキョウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 堅太郎"},{"creatorName":"カネコ, ケンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Kentaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00009545200.pdf","filesize":[{"value":"622.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00009545200.pdf","url":"https://dmu.repo.nii.ac.jp/record/1236/files/KJ00009545200.pdf"},"version_id":"9d617e95-3b33-4ce0-b16a-6d4116cb04fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"単純型熱性けいれん"},{"subitem_subject":"興奮性シナプス伝達"},{"subitem_subject":"パッチクランプ・ホールセル法"},{"subitem_subject":"syntaxin 1A"},{"subitem_subject":"歯状回"},{"subitem_subject":"Simple Febrile Seizures","subitem_subject_language":"en"},{"subitem_subject":"Excitatory Synaptic Transmission","subitem_subject_language":"en"},{"subitem_subject":"Tight-seal Whole-cell Recording","subitem_subject_language":"en"},{"subitem_subject":"Syntaxin 1a","subitem_subject_language":"en"},{"subitem_subject":"Dentate Dyrus","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス海馬歯状回における短時間の実験的熱性けいれんによる興奮性シナプス伝達への長期的影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス海馬歯状回における短時間の実験的熱性けいれんによる興奮性シナプス伝達への長期的影響"},{"subitem_title":"Long-term Effects of Brief Experimental Febrile Seizures on Excitatory Synaptic Transmission in the Mouse Hippocampal Dentate Gyrus","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"1236","relation_version_is_last":true,"title":["マウス海馬歯状回における短時間の実験的熱性けいれんによる興奮性シナプス伝達への長期的影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:00:17.347624+00:00"}