@article{oai:dmu.repo.nii.ac.jp:00001264,
 author = {渡部, 弥栄子 and 渡部, 功之 and 加納, 優治 and 刈屋, 桂 and 市川, 剛 and 栗林, 良多 and 坪井, 弥生 and 鈴村, 宏 and 有阪, 治 and Watabe, Yaeko and Watabe, Yoshiyuki and Kano, Yuji and Kariya, Katsura and Ichikawa, Go and Kuribayashi, Ryota and Tsuboi, Yayoi and Suzumura, Hiroshi and Arisaka, Osamu},
 issue = {2},
 journal = {Dokkyo journal of medical sciences},
 month = {Jul},
 note = {新生児遷延性肺高血圧症(persistent pulmonary hypertension of the newborn:PPHN)は,出生早期に肺高血圧症を発症し高度の低酸素血症を来す疾患である.正期産児のPPHNに対しては,NO吸入療法(inhaled nitric oxide:iNO)が有効とされているが,早産児における有効性は確立していない.今回,我々は在胎30週未満の早産児に対するiNOの有効性および安全性について検討した.対象は,出生後3日以内にiNOを施行した在胎30週未満の早産児39例である.肺高血圧の原因疾患は肺炎・敗血症が多かった.基礎疾患によって有効率が異なったが,iNO開始1時間の時点で全体の64%の症例はPPHNが改善した.PPHN改善後は速やかにiNOを減量・離脱できた症例が多かった.無効症例は週数・出生体重がより小さい児で多かった.有害事象としてはメトヘモグロビン血症を2例認めた.iNOは早産児のPPHNに対して,短期間の加療で出生早期の循環動態を改善させる有用な治療法であると考えられた., Persistent pulmonary hypertension of the newborn (PPHN) is a disease in which newborns develop pulmonary hypertension soon after birth, causing severe hypoxemia. Inhaled nitric oxide (iNO) therapy is effective in treating PPHN in term infants;however, the efficacy of iNO in preterm infants has not been established. We investigated the efficacy and safety of iNO as a treatment for preterm infants born at <30 weeks' gestation. The subjects were 39 preterm infants born at <30 weeks' gestation who underwent iNO therapy within 3 days of birth. The subjects' pulmonary hypertension was most commonly caused by pneumonia and sepsis. PPHN improved in 64 % of the subjects 1 hour after starting iNO. In many subjects, iNO was successfully reduced and withdrawn promptly after PPHN improved. Subjects in whom iNO was ineffective were commonly those born early and with lower birth weight. Mild methemoglobinemia was complicated in 2 subjects. In preterm infants with PPHN, iNO is a useful therapythat causes few adverse events and improves hemodynamics soon after birth within a short amount of time., 原著},
 pages = {71--75},
 title = {早産児の遷延性肺高血圧症に対するNO吸入療法の有効性・安全性の検討},
 volume = {42},
 year = {2015},
 yomi = {ワタベ, ヤエコ and ワタベ, ヨシユキ and カノウ, ユウジ and カリヤ, カツラ and イチカワ, ゴウ and クリバヤシ, リヨウタ and ツボイ, ヤヨイ and スズムラ, ヒロシ and アリサカ, オサム}
}