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  1. Dokkyo Journal of Medical Sciences
  2. 42(3) 2015

Protective Effects of Olmesartan and Azelnidipine against Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats

https://dmu.repo.nii.ac.jp/records/1271
https://dmu.repo.nii.ac.jp/records/1271
cb0a327f-3ec7-4d25-9129-37896a73321b
名前 / ファイル ライセンス アクション
KJ00010012900.pdf KJ00010012900.pdf (392.5 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Protective Effects of Olmesartan and Azelnidipine against Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats
言語 en
言語
言語 eng
キーワード
言語 en
主題 Hypertension
キーワード
言語 en
主題 Spontaneously Hypertensive Rat
キーワード
言語 en
主題 Angiotensin Ii Receptor Antagonist
キーワード
言語 en
主題 Calcium Channel Blocker
キーワード
言語 en
主題 Left Ventricular Hypertrophy
キーワード
言語 en
主題 Arteriosclerosis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Protective Effects of Olmesartan and Azelnidipine against Cardiovascular Organ Injuries in Spontaneously Hypertensive Rats
著者 Honda, Takeaki

× Honda, Takeaki

en Honda, Takeaki

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Furuichi, Masahito

× Furuichi, Masahito

en Furuichi, Masahito

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Murayama, Yoshiki

× Murayama, Yoshiki

en Murayama, Yoshiki

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Satonaka, Hiroshi

× Satonaka, Hiroshi

en Satonaka, Hiroshi

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Ishimitsu, Toshihiko

× Ishimitsu, Toshihiko

en Ishimitsu, Toshihiko

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著者所属(英)
en
Department Of Cardiology And Nephrology, Dokkyo Medical University
著者所属(英)
en
Department Of Cardiology And Nephrology, Dokkyo Medical University
著者所属(英)
en
Department Of Cardiology And Nephrology, Dokkyo Medical University
著者所属(英)
en
Department Of Cardiology And Nephrology, Dokkyo Medical University
著者所属(英)
en
Department Of Cardiology And Nephrology, Dokkyo Medical University
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 In the treatment of hypertension, care should be taken for preventing of hypertensive organ injuries as well as lowering blood pressure to the adequate level in order to reduce the risk of cardiovascular diseases. The purpose of this study is to examine the effects of angiotensin II receptor blockers (ARB), calcium channel blockers (CCB) and their combination on the development of cardiovascular organ injuries in spontaneously hypertensive rats (SHR). Four groups of male 8-week-old SHR (n=9 each) were given vehicle(control), 10 mg/kg azelnidipine (AZL), 10 mg/kg olmesartan (OLM, n=9), or the combination of AZL and OLM(5 mg/kg each)for 12 weeks, and their effects on cardiovascular organ injuries were evaluated. Tail-cuff blood at 12 weeks was similarly lowered by AML, OLM and the combination therapy(148, 143 and 143 mmHg, respectively)as compared with the control SHR (198 mmHg). Pulse rate was significantly less in the AZL group but not in the OLM group or the combination therapy group than in the untreated control group (-27, -12, +6 bpm, respectively). The cardiac ventricular weight (AZL -12%, OLM -15%, combination -18% vs. control) and aortic thickness (AZL -17%, OLM -16%, combination -19% vs. control) were reduced by similar extents in the three groups given antihypertensive treatments. Regarding the myocardial fibrosis, left ventricular hydroxyproline content was reduced in the OLM and the combination groups but the change was not significant in the AZL group (AZL -14%,OLM -30%, combination -27% vs. control). In the echocardiographic evaluation of cardiac function, the index of left ventricular diastolic function is significantly improved in the OLM and the combination groups but not in the AZL group, while the index of systolic function was not different between the four groups. It is suggested that the antihypertensive therapy including ARB is superior to the monotherapy by CCB in preventing the myocardial fibrosis and preserving the left ventricular diastolic function.
書誌情報 Dokkyo journal of medical sciences

巻 42, 号 3, p. 127-135, 発行日 2015-10-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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