@article{oai:dmu.repo.nii.ac.jp:00001274,
 author = {斉藤, 浩紀 and 中元, 明裕 and 片山, 裕視 and 鈴木, 一義 and 香川, 景政 and 須田, 季晋 and 草野, 祐実 and 小堀, 郁博 and 豊田, 紘二 and 寺内, 厳織 and 鈴木, 壱知 and 玉野, 正也 and Saito, Hiroki and Nakamoto, Akihiro and Katayama, Yasumi and Suzuki, Kazuyoshi and Kagawa, Kagemasa and Suda, Toshikuni and Kusano, Yumi and Kobori, Ikuhiro and Toyoda, Koji and Terauchi, Itsuo and Suzuki, Kazutomo and Tamano, Masaya},
 issue = {3},
 journal = {Dokkyo journal of medical sciences},
 month = {Oct},
 note = {目的:初発肝細胞癌の病因と予後規定因子について検討し,2000年の我々の獨協医科大学病院症例を対象とした報告と比較することを目的とした.方法:初発肝細胞癌102例を対象とした.病因はB型肝炎 (HBV),C型肝炎 (HCV),NBNC,アルコールの4つに分類した.Kaplan-Meier法を用いて生存率を求め,Coxの比例ハザードモデルを用いて予後因子の検討を行った.得られた結果を2000年の報告と比較した.結果:病因はHBV 12.8%,HCV 60.7%,NBNC 15.7%,アルコール10.8%であり,HCVは減少し,NBNCとアルコールは増加傾向にあった.治療例の生存率は1年87.5%,2年78.0%,3年71.5%であり,近年の診断と治療の進歩による予後改善が確認された.腫瘍ステージがIII以上であること,およびPIVKA-II 40 mAU/ml以上の2つが独立した予後規定因子であった.結論:肝細胞癌の病因ではHCVが減少し,NBNCとアルコールが増加していた.腫瘍ステージ,PIVKA-IIが独立した生命予後規定因子であった., Purpose:The purpose of this study was to investigate the causes of initial hepatocellular carcinoma and the factors determining prognosis, and to compare the findings with those of our year 2000 report.Method:Subjects comprised 102 patients with initial hepatocellular carcinoma. Causes were divided into four categories: hepatitis B virus (HBV);hepatitis C virus (HCV);non-B, non-C hepatitis (NBNC);and alcohol. Survival rates were obtained using the Kaplan-Meier method and prognostic factors were investigated using Cox's proportional hazards model. The results were compared with the findings of the year 2000 report.Results:The cause was HBV in 12.8 % of cases, HCV in 60.7%, NBNC in 15.7%, and alcohol in 10.8%. Frequency of HCV was decreased and frequencies of NBNC and alcohol showed increasing tendencies. The survival rate of treated patients was 87.5 % at 1 year, 78.0 % at 2 years, and 71.5 % at 3 years. Improved prognosis was confirmed with diagnosis in recent years and treatment advances. Two factors were independently associated with poor prognosis:tumor stage III or IV; and PIVKA-II level>40 mAU/ml.Conclusion:HCV decreased and NBNC and alcohol increased as causes of hepatocellular carcinoma. Factors independently associated with life prognosis were tumor stage and PIVKA-II level., 原著},
 pages = {151--157},
 title = {初発肝細胞癌の病因と予後規定因子に関する臨床的検討},
 volume = {42},
 year = {2015},
 yomi = {サイトウ, ヒロキ and ナカモト, アキヒロ and カタヤマ, ヤスミ and スズキ, カズヨシ and カガワ, カゲマサ and スダ, トシクニ and クサノ, ユウミ and コボリ, イクヒロ and トヨダ, コウジ and テラウチ, イツオ and スズキ, カズトモ and タマノ, マサヤ}
}