{"created":"2023-06-20T14:26:01.675216+00:00","id":1274,"links":{},"metadata":{"_buckets":{"deposit":"5e5b6646-d41c-467a-821c-798dfde492ab"},"_deposit":{"created_by":3,"id":"1274","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1274"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001274","sets":["81:75"]},"author_link":["6339","6342","6343","6347","6334","6341","6346","6349","6344","6330","6350","6335","6329","6328","6351","6345","6332","6331","6333","6338","6340","6337","6336","6348"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"157","bibliographicPageStart":"151","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"目的:初発肝細胞癌の病因と予後規定因子について検討し,2000年の我々の獨協医科大学病院症例を対象とした報告と比較することを目的とした.方法:初発肝細胞癌102例を対象とした.病因はB型肝炎 (HBV),C型肝炎 (HCV),NBNC,アルコールの4つに分類した.Kaplan-Meier法を用いて生存率を求め,Coxの比例ハザードモデルを用いて予後因子の検討を行った.得られた結果を2000年の報告と比較した.結果:病因はHBV 12.8%,HCV 60.7%,NBNC 15.7%,アルコール10.8%であり,HCVは減少し,NBNCとアルコールは増加傾向にあった.治療例の生存率は1年87.5%,2年78.0%,3年71.5%であり,近年の診断と治療の進歩による予後改善が確認された.腫瘍ステージがIII以上であること,およびPIVKA-II 40 mAU/ml以上の2つが独立した予後規定因子であった.結論:肝細胞癌の病因ではHCVが減少し,NBNCとアルコールが増加していた.腫瘍ステージ,PIVKA-IIが独立した生命予後規定因子であった.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Purpose:The purpose of this study was to investigate the causes of initial hepatocellular carcinoma and the factors determining prognosis, and to compare the findings with those of our year 2000 report.Method:Subjects comprised 102 patients with initial hepatocellular carcinoma. Causes were divided into four categories: hepatitis B virus (HBV);hepatitis C virus (HCV);non-B, non-C hepatitis (NBNC);and alcohol. Survival rates were obtained using the Kaplan-Meier method and prognostic factors were investigated using Cox's proportional hazards model. The results were compared with the findings of the year 2000 report.Results:The cause was HBV in 12.8 % of cases, HCV in 60.7%, NBNC in 15.7%, and alcohol in 10.8%. Frequency of HCV was decreased and frequencies of NBNC and alcohol showed increasing tendencies. The survival rate of treated patients was 87.5 % at 1 year, 78.0 % at 2 years, and 71.5 % at 3 years. Improved prognosis was confirmed with diagnosis in recent years and treatment advances. Two factors were independently associated with poor prognosis:tumor stage III or IV; and PIVKA-II level>40 mAU/ml.Conclusion:HCV decreased and NBNC and alcohol increased as causes of hepatocellular carcinoma. Factors independently associated with life prognosis were tumor stage and PIVKA-II level.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department Of Gastroenterology, Dokkyo Medical University Koshigaya Hospital"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ショハツ カンサイボウ ガン ノ ビョウイン ト ヨゴ キテイ インシ ニ カン スル リンショウ テキ ケントウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"斉藤, 浩紀"},{"creatorName":"サイトウ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中元, 明裕"},{"creatorName":"ナカモト, アキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"片山, 裕視"},{"creatorName":"カタヤマ, ヤスミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 一義"},{"creatorName":"スズキ, カズヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"香川, 景政"},{"creatorName":"カガワ, カゲマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"須田, 季晋"},{"creatorName":"スダ, トシクニ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"草野, 祐実"},{"creatorName":"クサノ, ユウミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小堀, 郁博"},{"creatorName":"コボリ, イクヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"豊田, 紘二"},{"creatorName":"トヨダ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺内, 厳織"},{"creatorName":"テラウチ, イツオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 壱知"},{"creatorName":"スズキ, カズトモ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉野, 正也"},{"creatorName":"タマノ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamoto, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Yasumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kazuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kagawa, Kagemasa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshikuni","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusano, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobori, Ikuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toyoda, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terauchi, Itsuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutomo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamano, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00010012903.pdf","filesize":[{"value":"574.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00010012903.pdf","url":"https://dmu.repo.nii.ac.jp/record/1274/files/KJ00010012903.pdf"},"version_id":"bc2e4993-20b1-40be-876d-e0f840f72f1e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝細胞癌"},{"subitem_subject":"病因"},{"subitem_subject":"予後規定因子"},{"subitem_subject":"PIVKA-II"},{"subitem_subject":"Hepatocellular Carcinoma","subitem_subject_language":"en"},{"subitem_subject":"Etiology","subitem_subject_language":"en"},{"subitem_subject":"Prognostic Factor","subitem_subject_language":"en"},{"subitem_subject":"Pivka-ii","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"初発肝細胞癌の病因と予後規定因子に関する臨床的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"初発肝細胞癌の病因と予後規定因子に関する臨床的検討"},{"subitem_title":"Clinical Analysis about Etiology and Prognostic Factors of Hepatocellular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["75"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"1274","relation_version_is_last":true,"title":["初発肝細胞癌の病因と予後規定因子に関する臨床的検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:01:38.702492+00:00"}