| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
The Effect of Switching from Either Mitiglinide or Glimepiride to Repaglinide on Both Glycemic Control and Oxidative Stress in Patients with Type 2 Diabetes |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
主題 |
Repaglinide |
| キーワード |
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|
言語 |
en |
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主題 |
Oxidative Stress |
| キーワード |
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|
言語 |
en |
|
主題 |
Type 2 Diabetes |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
The Effect of Switching from Either Mitiglinide or Glimepiride to Repaglinide on Both Glycemic Control and Oxidative Stress in Patients with Type 2 Diabetes |
| 著者 |
Inukai, Toshihiko
Takebayashi, Kohzo
Terasawa, Tomoko
Naruse, Rika
Hara, Kenji
Suetsugu, Mariko
Tuchiya, Takafumi
|
| 著者所属(英) |
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en |
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Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
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Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
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Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
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Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Aims:The goal of this study was to investigate the effect of switching from either the low dose sulfonylurea glimepiride(1?mg once daily)or the glinide mitiglinide(10?mg three times daily)to repaglinide(0.5?mg three times daily)on both glycemic control and oxidative stress in patients with type 2 diabetes.Patients and Methods:Finally 17 patients(patients treated with either glimepiride:n=11 or mitiglinide:n=6)completed the study. The type and dose of all drugs, including the anti-diabetic treatments, were not changed for at least 1?month prior to the study.Results:Both groups showed a significant decrease in HbA1c levels. FPG showed a tendency(not significant)toward a decrease in the mitiglinide-treated group, while no change was found in the glimepiride-treated group. A significant decrease in 8-iso-PGF2α levels was found only in the glimepiride-treated group. There was a significant correlation between the difference in 8-iso-PGF2α levels and that in either FPG or HbA1c before and after the switch only in the mitiglinide-treated group.Conclusions:Repaglinide may have an anti-oxidative effect probably due to the strong postprandial glucose lowering observed in patients with type 2 diabetes. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 43,
号 1,
p. 5-13,
発行日 2016-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00010141600.pdf (370.9 kB)
