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  1. Dokkyo Journal of Medical Sciences
  2. 43(1) 2016

The Effect of Switching from Either Mitiglinide or Glimepiride to Repaglinide on Both Glycemic Control and Oxidative Stress in Patients with Type 2 Diabetes

https://dmu.repo.nii.ac.jp/records/1289
https://dmu.repo.nii.ac.jp/records/1289
93f37cf2-20bf-4974-92e2-911eaa66d806
名前 / ファイル ライセンス アクション
KJ00010141600.pdf KJ00010141600.pdf (370.9 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル The Effect of Switching from Either Mitiglinide or Glimepiride to Repaglinide on Both Glycemic Control and Oxidative Stress in Patients with Type 2 Diabetes
言語 en
言語
言語 eng
キーワード
言語 en
主題 Repaglinide
キーワード
言語 en
主題 Oxidative Stress
キーワード
言語 en
主題 Type 2 Diabetes
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル The Effect of Switching from Either Mitiglinide or Glimepiride to Repaglinide on Both Glycemic Control and Oxidative Stress in Patients with Type 2 Diabetes
著者 Inukai, Toshihiko

× Inukai, Toshihiko

en Inukai, Toshihiko

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Takebayashi, Kohzo

× Takebayashi, Kohzo

en Takebayashi, Kohzo

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Terasawa, Tomoko

× Terasawa, Tomoko

en Terasawa, Tomoko

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Naruse, Rika

× Naruse, Rika

en Naruse, Rika

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Hara, Kenji

× Hara, Kenji

en Hara, Kenji

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Suetsugu, Mariko

× Suetsugu, Mariko

en Suetsugu, Mariko

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Tuchiya, Takafumi

× Tuchiya, Takafumi

en Tuchiya, Takafumi

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著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
著者所属(英)
en
Department Of Internal Medicine, Dokkyo Medical University Koshigaya Hospital
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Aims:The goal of this study was to investigate the effect of switching from either the low dose sulfonylurea glimepiride(1?mg once daily)or the glinide mitiglinide(10?mg three times daily)to repaglinide(0.5?mg three times daily)on both glycemic control and oxidative stress in patients with type 2 diabetes.Patients and Methods:Finally 17 patients(patients treated with either glimepiride:n=11 or mitiglinide:n=6)completed the study. The type and dose of all drugs, including the anti-diabetic treatments, were not changed for at least 1?month prior to the study.Results:Both groups showed a significant decrease in HbA1c levels. FPG showed a tendency(not significant)toward a decrease in the mitiglinide-treated group, while no change was found in the glimepiride-treated group. A significant decrease in 8-iso-PGF2α levels was found only in the glimepiride-treated group. There was a significant correlation between the difference in 8-iso-PGF2α levels and that in either FPG or HbA1c before and after the switch only in the mitiglinide-treated group.Conclusions:Repaglinide may have an anti-oxidative effect probably due to the strong postprandial glucose lowering observed in patients with type 2 diabetes.
書誌情報 Dokkyo journal of medical sciences

巻 43, 号 1, p. 5-13, 発行日 2016-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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