@article{oai:dmu.repo.nii.ac.jp:00000139,
 author = {井上, 有方 and Inoue, Yuhou},
 issue = {2},
 journal = {Dokkyo journal of medical sciences},
 month = {Jul},
 note = {OnPump冠動脈バイパス術(CCABG)とOffPump CABG(OPCABG)において1)過去10年間の術後脳梗塞発症頻度2)術前MRAで測定したCCABG 22例,OPCAB25例の内頸,椎骨動脈血流量3)CCABG8例,OPCABIO例の周術期血清S-100蛋白濃度について比較検討し,CABG術後脳梗塞予防にPOCABが有用かどうか検討した。脳梗塞発症率はCCABG群1.5%(9/598),OPCAB群1.0%(1/100)で差を認めなかった。CCABG群の内頸,椎骨動脈血流量は441.1±98.9,165.1±56.2ml/min,OPCAB群は373±86.3,148±529ml/minで,ともにOPCAB群が有意(P<0.05)に少なかった。CCABG群のS-100蛋白は4.1±2.0 μg/L,OPCAB群は0.7±0.4 μg/LでOPCAB群が有意(P<0.05)に低かった。OPCAB群はCCABG群に比べ頸動脈血流量が有意に低いにもかかわらず,S-100蛋白の上昇は軽微であったことから,OPCABは術後脳梗塞の予防に有用である可能性が示唆された。, Cerebral infarction is an important complication after coronary artery bypass grafting (CABG). To investigate superiority of off - pump CABG over on-pump CABG in terms of reducing risk ot the complication, we reviewed frequency of cerebral infarction of 698 patients who underwent CABG at our hospiati for a recent decade. Magnetic resonance angiography (MRA) of internal carotid artery (ICA) and vertebral artery (VA) was performed and the blood flow volumes were obtained in 47 patients for identifying those at the increased risk of postoperative cerebral infarction. Serum S-100β release was also measured in 18 patients to investigate early postoperative brain damage. Postoperative cerebral infarction occured in 9 of 598 (1.5%) on-pump CABG patients and 1 of 100 (1.0%) off-pump CABG patients. There was no difference in the frequency between the two procedures. The blood flow volumes of ICA and VA were significantly smaller (P < 0.05) in 25 off-pump CABG patients (ICA : 373.6 ± 86.3 ml/min, VA : 148.6 ± 52.9 ml/min) than 22 on-pump CABG patients (ICA 441.1 ± 98.9 ml/min, VA :165.1 ± 56.2 ml/min). Concentration of serum S-100β 30 minutes after surgery in off - pump CABG patients was lower in spite f the smaller blood flow volumes of neck arteries suggested that off-pump CABG is superior to on-pump CABG to reduce the risk of postoperative cerebral infarction., 原著, Original},
 pages = {153--161},
 title = {冠動脈バイパス術後脳梗塞予防におけるOffPump術式の有用性について : 特に術前のMagnetic Resonance Angiography (MRA)による頸動脈,椎骨動脈血流量及び血清S-100蛋白の周術期変動からみて},
 volume = {30},
 year = {2003},
 yomi = {イノウエ, ユウホウ}
}