{"created":"2023-06-20T14:26:09.161904+00:00","id":1477,"links":{},"metadata":{"_buckets":{"deposit":"4785f024-3bce-48e4-92a0-396ce35b1d10"},"_deposit":{"created_by":14,"id":"1477","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"1477"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001477","sets":["81:86"]},"author_link":["4317","6347","6571","6334","5134","6916","5124","6917","6918","6204","5115","5136","6335","5146","572","1912","4306","6205","1591","6919","6206","6562"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"47","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_34":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":"目的：C型慢性肝炎患者に対するインターフェロン(IFN)療法後の肝発癌について検討した．\n方法：C型慢性肝炎に対してIFN療法が施行された180例を対象とした．非発癌群と発癌群の間で，治療前の背景因子と半年後のウイルス学的著効(SVR24)の有無，治療後のALT，AFPについて比較した．また，それぞれの因子別に発癌曲線を作成して発癌率を比較した．\n結果：IFN治療によるSVR24の達成率は68.9％(124/180)であり，36.3ヶ月の観察期間で全体の発癌率は2.3％(5/180)であった．発癌群では非発癌群に比べ，高齢者，男性，SVR24非達成例，ALT高値例が多い傾向にあった．治療後のALT高値，AFP高値例は発癌が多かったが，特にAFPでは統計学的な有意差を認めた．\n結論：IFN治療前の線維化進展例と高齢者，男性，治療後ALT高値，AFP高値は肝発癌率が高い傾向にある．特に治療後AFP高値は肝発癌予測因子になる．","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"},{"subitem_text_value":"獨協医科大学越谷病院 消化器内科"}]},"item_10001_text_25":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"}]},"item_10001_text_28":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_text_value":"8"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"原著"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"草野, 祐実"},{"creatorName":"クサノ, ユウミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"片山, 裕視"},{"creatorName":"カタヤマ, ヤスミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中元, 明裕"},{"creatorName":"ナカモト, アキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北川, 智之"},{"creatorName":"キタガワ, トモユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"須田, 季晋"},{"creatorName":"スダ, トシクニ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大川, 修"},{"creatorName":"オオカワ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北濱, 彰博"},{"creatorName":"キタハマ, アキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小堀, 郁博"},{"creatorName":"コボリ, イクヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"豊田, 紘二"},{"creatorName":"トヨダ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"徳富, 治彦"},{"creatorName":"トクトミ, ナオヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉野, 正也"},{"creatorName":"タマノ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kusano, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Yasumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamoto, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitagawa, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshikuni","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okawa, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitahama, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobori, Ikuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toyoda, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokutomi, Naohiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamano, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"DJMS-44-1-8.pdf","filesize":[{"value":"636.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DJMS-44-1-草野-本文","url":"https://dmu.repo.nii.ac.jp/record/1477/files/DJMS-44-1-8.pdf"},"version_id":"15e12007-db58-43e6-892a-97203af68be3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C型慢性肝炎","subitem_subject_scheme":"Other"},{"subitem_subject":"インターフェロン","subitem_subject_scheme":"Other"},{"subitem_subject":"ウイルス学的著効（SVR)肝発癌","subitem_subject_scheme":"Other"},{"subitem_subject":"a-feto protein（AFP）","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic hepatitis C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sustained virological response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocarcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"a-feto protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C 型肝炎患者に対するインターフェロン療法後の肝発癌についての検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C 型肝炎患者に対するインターフェロン療法後の肝発癌についての検討"}]},"item_type_id":"10001","owner":"14","path":["86"],"publish_date":"2018-07-09","publish_status":"0","recid":"1477","relation_version_is_last":true,"title":["C 型肝炎患者に対するインターフェロン療法後の肝発癌についての検討"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T15:44:51.396894+00:00"}