{"created":"2023-06-20T14:26:09.302359+00:00","id":1479,"links":{},"metadata":{"_buckets":{"deposit":"c973711f-101c-40db-aaa9-9b12ff65a34b"},"_deposit":{"created_by":14,"id":"1479","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"1479"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00001479","sets":["81:86"]},"author_link":["6923","6922"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"71","bibliographicPageStart":"63","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_34":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":"小児期のセボフルラン曝露は長期認知機能障害の原因となる可能性が示唆されている．本研究では，セボフルラン曝露による認知機能障害のメカニズムに細胞内Cl－濃度バランスが与える影響を明らかにする目的で，新生仔マウスにNKCC1阻害薬であるブメタニドを投与し，セボフルラン曝露マウスの認知行動を観察した．ICRマウス(生後3〜5日，11〜13日，19〜21日)を2.1％セボフルランに4時間曝露，生後49日目に水迷路試験，オープンフィールド試験，プレパルス抑制試験を施行した．また新生仔マウス（生後3〜5日）にブメタニドを腹腔内投与し，注射直後にセボフルランに曝露させ，行動試験を行い，対照群と比較した．生後3〜5日目にセボフルランに曝露させたマウスでは，対照マウスと比較して水迷路試験における遊泳距離の増加，オープンフィールド試験における移動距離と立ち上がり回数の増加，プレパルスによる驚愕反応抑制の低下を示した．一方，これらの変化は，ブメタニドにより抑制された．新生仔期のセボフルラン誘発性認知機能障害に，細胞内Cl－濃度の増加によって起こるGABAA受容体を介した脱分極が関与している可能性が示唆された．","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学医学部 麻酔科学"}]},"item_10001_text_25":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology, Dokkyo Medical University, Tochigi, Japan"}]},"item_10001_text_28":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_text_value":"10"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"原著"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"秦, 要人"},{"creatorName":"ハタ, カナト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"6922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hata, Kanato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6923","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-09"}],"displaytype":"detail","filename":"DJMS-44-1-10.pdf","filesize":[{"value":"526.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DJMS-44-1-秦-本文","url":"https://dmu.repo.nii.ac.jp/record/1479/files/DJMS-44-1-10.pdf"},"version_id":"e2c0c6a0-2b5d-4b55-9e51-f24066246117"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"セボフルラン","subitem_subject_scheme":"Other"},{"subitem_subject":"新生仔マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"認知機能障害","subitem_subject_scheme":"Other"},{"subitem_subject":"GABA","subitem_subject_scheme":"Other"},{"subitem_subject":"ブメタニド","subitem_subject_scheme":"Other"},{"subitem_subject":"sevoflurane","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neonatal mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cognitive dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bumetanide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"behavioral tests","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ブメタニドはマウス新生仔期セボフルラン曝露による認知機能障害を予防する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ブメタニドはマウス新生仔期セボフルラン曝露による認知機能障害を予防する"},{"subitem_title":"Bumetanide Prevents the Neonatal Sevoflurane-induced Cognitive Dysfunction in Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["86"],"publish_date":"2018-07-09","publish_status":"0","recid":"1479","relation_version_is_last":true,"title":["ブメタニドはマウス新生仔期セボフルラン曝露による認知機能障害を予防する"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T15:44:55.692077+00:00"}