@article{oai:dmu.repo.nii.ac.jp:00001494,
 author = {Iwahata, Toshiyuki and Kobori, Yoshitomo and Shimomura, Yukihito and Suzuki, Keisuke and Shin, Takeshi and Song, Shigehiro and Okada, Hiroshi},
 issue = {2},
 journal = {Dokkyo Journal of Medical Sciences},
 month = {Jul},
 note = {Genetic factors are responsible for approximately 15％ of male infertility. The azoospermia factors AZFa, AZFb（P5/proximal P1）, and AZFc（b2/b4） present on Yq are most important for spermatogenesis. Here,
we evaluated frequencies of microdeletions of AZFa, AZFb, AZFc in azoospermia due to spermatogenic
dysfunction in the Japanese population. The overall prevalence of Y chromosome microdeletions in infertile
men was 8.1％（79/980）. The prevalence of Y chromosome microdeletions in AZFa, AZFb, AZFabc, AZFbc （P5/distal P1 or P4/distal P1） and AZFc was 0.1％ , 0.8％ , 0.7％ , 2.0％ and 4.4％ , respectively. Microdissection for testicular sperm extraction failed in all patients with microdeletion in AZFa, AZFb, AZFabc, and AZFbc, although sperm could be retrieved in 28/43 patients with AZFc deletions（62.2％）. The presence of an AZFc deletion was associated with significantly better sperm retrieval than the 33.0％ retrieval rate in idiopathic non-deleted azoospermic men undergoing microdissection for testicular sperm
extraction at our institution during the study period. We conclude that Y chromosome microdeletion testing is essential for genetic and preoperative counseling in these patients.},
 pages = {151--155},
 title = {Spermatogenic Dysfunction in Azoospermic Japanese Men Caused by Y Chromosome Microdeletions},
 volume = {44},
 year = {2017}
}