@article{oai:dmu.repo.nii.ac.jp:00001532,
 author = {Hirofumi, Hashimoto},
 issue = {3},
 journal = {Dokkyo Journal of Medical Sciences},
 month = {Oct},
 note = {The calcitonin gene-related peptide (CGRP) family is composed of CGRP, adrenomedullin (AM), AM2 (identical to intermedin), AM5 and amylin. These peptides are widely distributed in peripheral tissues and the central nervous system (CNS). They activate a cAMP-dependent pathway via complexes of calcitonin receptor or calcitonin receptor-like receptor and receptor activity-modifying proteins. They are involved in several physiological and pathological functions such as water intake, feeding, and modulation of cardiovascular and neuroendocrine systems. Previous studies have shown that a central administration of these neuropeptides activated various areas in the CNS and induced physiological effects. Our previous studies showed that centrally administered AM family (AM, AM2 and AM5) induces the expressions of the c-fos gene in the oxytocin-secreting neurons in the supraoptic and the paraventricular nuclei of the hypothalamus and elicits a marked increase in plasma oxytocin levels in conscious rats. Here, I review the roles of the CGRP family in the CNS.},
 pages = {239--256},
 title = {Roles of the Calcitonin Gene-Related Peptide Family in the Central Nervous System},
 volume = {44},
 year = {2017}
}