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Preservation of Renal Function in Predialysis Patients before Dialysis Initiation with Nephrology Care: A Single-center Retrospective Study
https://dmu.repo.nii.ac.jp/records/2000007
https://dmu.repo.nii.ac.jp/records/2000007fa01c1ae-081f-46fa-b2b0-378d49c090bc
| 名前 / ファイル | ライセンス | アクション |
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DKMJ-2-1-3.pdf (113 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| タイトル | ||||||||||||||
| タイトル | Preservation of Renal Function in Predialysis Patients before Dialysis Initiation with Nephrology Care: A Single-center Retrospective Study | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | access preparation | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | dialysis initiation | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | nephrology care | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | predialysis CKD patients | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | vitamin D | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Kawamoto, Shinya
× Kawamoto, Shinya
× Nagahori, Katsuhiro
× Yasu, Takanori
× Takeda, Tetsuro
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| 書誌情報 |
Dokkyo Medical Journal 巻 2, 号 1, p. 16-22, 発行日 2023-03-25 |
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| 記事種別 | ||||||||||||||
| Original | ||||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Background: Progressive chronic kidney disease, which necessitates dialysis, results in inability to maintain renal homeostasis. Although drugs are available, maintenance of residual renal function is challenging, and the estimated glomerular filtration rate (eGFR) declines rapidly. Age, sex, primary disease of renal failure, blood pressure, urinary protein, anemia, and access preparation for dialysis affect the decline in eGFR during this period. Methods: We investigated 428 incident dialysis patients who received nephrology care for >6 months before dialysis initiation. We retrospectively compared age, primary disease (diabetic vs. non-diabetic kidney disease), blood pressure, serum hemoglobin levels, urinary protein levels, renin-angiotensin system (RAS) inhibitor, diuretics, vitamin D use and preparation of access at initiation to determine their association with the decline in eGFR over 6 months before dialysis initiation. Result: The decline in eGFR was significantly associated with age (<60 years), sex (male), without access preparation, hypertension (6 months before and at initiation), renin-angiotensin system inhibitor use (6 months prior), nephrotic-range proteinuria, and vitamin D use. We observed no significant differences in the primary disease (diabetic vs. non-diabetic kidney disease), RAS inhibitor use and hemoglobin levels at initiation. RAS inhibitors are also effective in CKDG1 to G4, whereas they are not effective in CKD with advanced G5. Multivariate analysis showed that eGFR decline was significantly correlated with sex, vascular access preparation, and urinary protein levels. Conclusion: Renal function preservation is challenging in patients with progressive chronic kidney disease accompanied by increased urinary protein levels. Regardless of renin-angiotensin system inhibitor use, renal function was better preserved in women with strict blood pressure control and vascular access preparation before dialysis initiation. |
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| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Dokkyo Medical Society | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 2436-522X | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2022-029 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
