{"created":"2023-08-31T05:35:35.949576+00:00","id":2000009,"links":{},"metadata":{"_buckets":{"deposit":"a04a302a-5bc2-4b6d-8e96-adef7bb89196"},"_deposit":{"created_by":14,"id":"2000009","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2000009"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:02000009","sets":["223:1693284286865"]},"author_link":[],"control_number":"2000009","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"42","bibliographicPageStart":"31","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Dokkyo Medical Journal"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Aims: The current study was performed to evaluate the association between the accumulation of advanced glycation end-products (AGEs) in skin and diabetes-related metabolic markers, atherosclerosis and diabetic complications in patients with poorly-controlled type 2 diabetes.\n\nMethods: The skin AGE levels were assessed non-invasively by measuring skin autofluorescence (SAF). The modified low-density lipoprotein (LDL) was assessed by measuring lectin-like oxidized LDL receptor-1 ligand-containing apolipoprotein B (LAB).\n\nResults: SAF was significantly higher in patients with type 2 diabetes than in the healthy control subjects. In patients with type 2 diabetes, SAF correlated positively with age and duration of diabetes. Furthermore, SAF exhibited significant negative correlations with LDL-cholesterol (C), triglyceride (TG) and body mass index. SAF was also negatively correlated with urinary C peptide immunoreactivity (U-CPR). In addition, SAF also exhibited significant positive correlations with cardio-ankle vascular index (CAVI) and intimal medial complex thickness of the carotid artery (IMT). Furthermore, there were significant correlations between SAF and estimated glomerular filtration rate (eGFR) (negative), urinary albumin excretion (positive).\n\nConclusion: SAF may be negatively associated with serum lipids such as LDL-C and TG, insulin sensitivity ability and renal dysfunction evaluated by eGFR, and positively associated with aging, duration of diabetes, markers of atherosclerosis (CAVI and IMT) in patients with poorly-controlled type 2 diabetes.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dokkyo Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.51040/dkmj.2022-041","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-522X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takebayashi, Kohzo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuchiya, Takafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shinozaki, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamauchi, Mototaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Tatsuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hara, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inukai, Toshihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hashimoto, Koshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-31"}],"filename":"DKMJ-2-1-5.pdf","filesize":[{"value":"175 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://dmu.repo.nii.ac.jp/record/2000009/files/DKMJ-2-1-5.pdf"},"version_id":"54d5f075-f439-4138-b00d-a8cfa9b01a6f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-31"}],"filename":"DKMJ-2-1-5-Suppl.pdf","filesize":[{"value":"996 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://dmu.repo.nii.ac.jp/record/2000009/files/DKMJ-2-1-5-Suppl.pdf"},"version_id":"8959cc1d-c0cf-4cc6-ad60-415511a6bde7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SAF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LDL-C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"U-CPR","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of Skin Autofluorescence with Serum Lipids, Insulin Secretion Ability and Diabetic Complications in Patients with Poorly Controlled Type 2 Diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of Skin Autofluorescence with Serum Lipids, Insulin Secretion Ability and Diabetic Complications in Patients with Poorly Controlled Type 2 Diabetes","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["1693284286865"],"publish_date":"2023-08-31","publish_status":"0","recid":"2000009","relation_version_is_last":true,"title":["Association of Skin Autofluorescence with Serum Lipids, Insulin Secretion Ability and Diabetic Complications in Patients with Poorly Controlled Type 2 Diabetes"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-10-16T03:31:51.540725+00:00"}