| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Association between Blood IGF-1 Levels and Functional Prognosis in Hyperacute Ischemic Stroke Patients Undergoing Thrombolytic Therapy |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Insulin-like growth factor-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hyperacute ischemic stroke |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
recombinant tissue-type plasminogen activator |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kobayashi, Saro
Takekawa, Hidehiro
Iwasaki, Akio
Suzuki, Keisuke
|
| 書誌情報 |
Dokkyo Medical Journal
巻 2,
号 1,
p. 57-64,
発行日 2023-03-25
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| 記事種別 |
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|
値 |
Original |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Insulin-like growth factor-1 (IGF-1) is associated with the functional prognosis in cerebral infarction patients. However, no studies have been performed on patients who underwent intravenous thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA). Fifty-five patients with hyperacute ischemic stroke within six hours of onset who were admitted to our hospital and underwent intravenous thrombolytic therapy and gave consent were included in this study. Serum IGF-1 levels were measured within 24 hours of stroke onset, and their association with the following data was assessed: age, sex, body mass index (BMI), medical history, blood D-dimer level, BNP level, blood glucose level, renal function, stroke subtype, infarct size, National Institutes of Health Stroke Scale (NIHSS) at stroke onset, and modified Rankin Scale (mRS) at three months. The good outcome group (mRS 0-1) had significantly higher serum IGF-1 levels than the poor outcome group (mRS ≥ 2, median 83 ng/mL vs. 62 ng/mL, p 0.032). Furthermore, the good outcome group was significantly younger than the poor outcome group (p < 0.001) which had higher BMI (p = 0.021), had lower D-dimer (p = 0.032) and BNP (p = 0.026) levels. There was no difference in NIHSS at onset, and the IGF-1 correlation was eliminated by age-adjustment. Serum IGF-1 levels may correlate with prognosis at three months after stroke in patients with hyperacute ischemic stroke treated with intravenous thrombolytic therapy, but the effect of age is also strong. Further studies that focus on specific age groups, include large number of patients, and evaluate mechanical thrombectomy at multiple institutions are needed. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Dokkyo Medical Society |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2436-522X |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2022-047 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-2-1-7.pdf (263 KB)
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