| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Treatment Strategy for Pediatric Patients with Nephrotic Syndrome with Microscopic Hematuria at the Onset: A Retrospective Study of the Need for Kidney Biopsy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Child |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hematuria |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Kidney biopsy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Minimal change disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nephrotic syndrome |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kano, Yuji
Takagi, Yuhi
Imataka, George
Yoshihara, Shigemi
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 2,
号 2,
p. 114-122,
発行日 2023-06-25
|
| 記事種別 |
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|
値 |
Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Nephrotic syndrome (NS) in children responds well to steroid therapy, therefore kidney biopsy before treatment is often avoided. However, the indications for kidney biopsy in children with NS with microscopic hematuria are controversial. In the present study, the indications for pretreatment kidney biopsy at the onset of pediatric patients with NS with microscopic hematuria were evaluated. Clinicopathologic correlations were retrospectively examined from patients enrolled in a database from January 2005 to December 2018. Fifty-nine pediatric patients with NS were enrolled. Among them, 6 with hypocomplementemia, gross hematuria, or onset at less than 1 year of age were excluded. Of the 53 enrolled patients, 38 without hematuria were assigned to Group A, and 15 patients with microscopic hematuria comprised Group B. There was a significant difference in the renal biopsy rate between Group A (n = 19, 50%) and Group B (n = 13, 87%) (P = 0.01). Two patients in Group B avoided biopsy. Pathology results for patients in Group B included 4 patients with minimal change disease, 2 with focal segmental glomerulosclerosis, 6 with mesangial proliferative glomerulonephritis (non-IgA), and 1 with membranous lupus nephritis (LN). The first three are commonly found in pediatric patients with NS, and all are treated with steroid therapy. LN could be diagnosed by kidney biopsy at the time of steroid resistance. LN presenting with nephrotic syndrome is also treated with steroids. Thus, the treatment strategy would not have changed even if the kidney biopsy had been performed before treatment. These results suggest that renal biopsy is not always mandatory during the initial stage for pediatric patients with NS with microscopic hematuria. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2022-055 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-2-1-3.pdf (183 KB)
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