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Development of a Young Rat Hyperkalemia Model with Decreased Renal Excretion of Potassium
https://dmu.repo.nii.ac.jp/records/2000045
https://dmu.repo.nii.ac.jp/records/2000045018eb036-c050-489b-b845-443d23de3c44
| 名前 / ファイル | ライセンス | アクション |
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DKMJ-2-1-6.pdf (349 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| タイトル | ||||||||||||||||
| タイトル | Development of a Young Rat Hyperkalemia Model with Decreased Renal Excretion of Potassium | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Amiloride | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Angiotensin II type 2 receptor agonist | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Compound 21 | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Pediatrics | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Renal hyperkalemia | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Takagi, Yuhi
× Takagi, Yuhi
× Yamada, Teppei
× Tanaka-Nakadate, Sawako
× Fujita, Tomoe
× Yoshihara, Shigemi
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 2, 号 2, p. 138-147, 発行日 2023-06-25 |
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| 記事種別 | ||||||||||||||||
| en | ||||||||||||||||
| Original | ||||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Infants and young children are prone to hyperkalemia caused by decreased renal potassium excretion. However, there are limitations to the use of current hyperkalemia drugs in pediatric patients. To address this issue, we developed a young rat hyperkalemia model by the combined administration of potassium chloride (KCl) and amiloride (Ami) to test new drug candidates for young patients. We administered KCl (2, 3, 4.5, and 6 mEq/kg) and Ami (3 mg/kg) intraperitoneally to five-week-old male Wistar-Imamichi rats and placed them in metabolic cages. After 6 h, blood and urine samples were collected. The combined administration of KCl and Ami increased the serum-potassium concentration compared to the control (2 mEq/kg; 5.2 vs 4.5 mEq/L, P ＝ 0.039, 6 mEq/kg; 6.8 vs 4.1 mEq/L, P = 0.005, n = 5) in a dose-dependent manner. Next, the rats were orally administered furosemide (30 mg/kg, FURO), a known hyperkalemia treatment, or Compound 21 (C21) (10 and 30 mg/kg), an angiotensin II type 2 receptor agonist and candidate drug for hyperkalemia. FURO was administered as a single dose (after 1 h) or as repeated doses (after 1, 3, and 5 h). The serum-potassium concentration was significantly decreased by FURO (single dose; 5.9 vs 6.8 mEq/L, P = 0.017, n = 7, repeated doses; 5.6 vs 6.3 mEq/L, P = 0.021, n = 7). However, C21 did not decrease the serum-potassium concentration compared to the control (6.6 vs 6.8 vs 7.2 mEq/L, P = 0.07). Overall, this model can be used to evaluate the effects of candidate therapeutic drugs for hyperkalemia in school children caused by decreased urinary-potassium excretion. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Dokkyo Medical Society | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2436-522X | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA12941861 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2022-064 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
