{"created":"2024-02-01T04:57:13.983451+00:00","id":2000103,"links":{},"metadata":{"_buckets":{"deposit":"442d5402-8130-49ab-8bef-880d0412f89a"},"_deposit":{"created_by":14,"id":"2000103","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2000103"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:02000103","sets":["81:1706758513382"]},"author_link":[],"control_number":"2000103","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"122","bibliographicPageStart":"111","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"低身長の原因である成長ホルモン分泌不全/成長ホルモン欠損症（growth hormone （GH） deficiency：GHD）の治療のために，ヒト下垂体から抽出した GH 製剤（pituitary-derived human GH：phGH）が日本では 1975年に承認されたが，供給量は限られており，すべての GHD による低身長児に投与することはできなかった．しかし，1988 年に遺伝子組換え hGH （recombinant hGH：rhGH）が開発され，それ以降 rhGH が十分に供給されるようになり，GH 治療の状況は劇的に改善した．また，GH-IGF-I （Insulin-like growth factor-I） 軸の成長調節機構がより解明されたため, rhGH は GHD に対する補充投与だけでなく，薬理学的治療として高用量 GH が一部の GH 分泌不全のない非 GHD 低身長児の治療にも使用されるようになった．\n　GH 治療の安全性への懸念としては，GH の抗インスリン作用と細胞増殖活性に関連する 2 型糖尿病と白血病の発生であるが，長期調査の結果，現在，小児における rhGH の投与は安全と考えられている．GH 治療の将来については，2021 年に週 1 回の投与ですむ持続型 GH 製剤が開発され，毎日の自己注射が不要となった．その結果，成長ホルモン治療のアドヒアランスが向上し，良好な治療効果が得られることが期待される．\n　本総説では小児の低身長に対する GH 治療の進歩について述べた．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-5023","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有阪, 治","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"小山, さとみ","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"今高, 城治","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"市川, 剛","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"西連地, 利己","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"大日方, 薫","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"中山, 有子","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-01"}],"filename":"DJMS-50-2-7.pdf","filesize":[{"value":"901 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://dmu.repo.nii.ac.jp/record/2000103/files/DJMS-50-2-7.pdf"},"version_id":"b3345222-0d8a-48e5-b9e9-009dd5f931de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"低身長症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"成長ホルモン分泌不全/成長ホルモン欠損症（GHD）","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子組み換えヒト成長ホル モン（rhGH）","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン様成長因子 I（IGF-I）","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アドヒアランス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低身長児に対する成長ホルモン治療の進歩について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低身長児に対する成長ホルモン治療の進歩について","subitem_title_language":"ja"},{"subitem_title":"Progress in Growth Hormone Treatment for Short Stature Children","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["1706758513382"],"publish_date":"2024-02-01","publish_status":"0","recid":"2000103","relation_version_is_last":true,"title":["低身長児に対する成長ホルモン治療の進歩について"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2024-08-29T03:55:33.511351+00:00"}