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An Easy Z-score Imaging System for Discrimination Between Alzheimer's Disease and Dementia with Lewy Bodies Using Brain Perfusion SPECT
https://dmu.repo.nii.ac.jp/records/2000179
https://dmu.repo.nii.ac.jp/records/200017989d3a058-297d-43ad-9a4e-f25728a81a8e
| 名前 / ファイル | ライセンス | アクション |
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DKMJ-2-4-6.pdf (706 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| タイトル | ||||||||||||
| タイトル | An Easy Z-score Imaging System for Discrimination Between Alzheimer's Disease and Dementia with Lewy Bodies Using Brain Perfusion SPECT | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Akaiwa, Yasuhisa
× Akaiwa, Yasuhisa
× Numahata, Kyoko
× Miyamoto, Tomoyuki
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 2, 号 4, p. 295-303, 発行日 2023-12-25 |
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| Original | ||||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Objective: We retrospectively examined whether easy Z-score imaging system (eZIS)-specific volume of interest analysis (SVA) using brain perfusion single photon emission computed tomography (SPECT) imaging or the cingulate island sign score (CIScore) could distinguish between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Methods: This study included 22 AD and 22 DLB patients who underwent 99mTc-ECD SPECT at Dokkyo Medical University Saitama Medical Center from November 2011 to February 2023. Results: The SVA of AD and DLB patients showed that the threshold was exceeded in 77.3% for severity, 72.7% for extent, and 63.6% for ratio in AD, and in 86.4% for severity, 77.3% for extent, and 72.7% for ratio in DLB, with no significant difference between the two patient groups. The CIScore threshold of 0.281 allowed DLB to be discriminated from AD with an accuracy, sensitivity, and specificity of 63.6%, 77.2%, and 50.0%, respectively. The mean CIScore was significantly lower in DLB patients than in AD patients (p = 0.028, Mann-Whitney U test). A significant positive correlation was found between the CIScore and age of AD and DLB patients by Spearman's rank correlation coefficient analysis. Conclusion: SVA is useful for the diagnosis of dementia with AD and DLB. CIScore is an adjunctive assessment method to distinguish between AD and DLB. Although CIScore can distinguish AD and DLB, it was strongly affected by age. |
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| 言語 | en | |||||||||||
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| 出版者 | Dokkyo Medical Society | |||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2436-522X | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA12941861 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2023-018 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
