| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Protein Synthesis Inhibitors Induce the Sodium/Iodide Symporter Expression in Various Human Cancer Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
protein synthesis inhibitor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sodium/iodide symporter |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cycloheximide |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
homoharringtonine |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kato, Kanako
Ito, Yuka
Sakumoto, Junko
Namatame, Takashi
Hishinuma, Akira
Kogai, Takahiko
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 1,
p. 7-15,
発行日 2024-03-25
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| 記事種別 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Radioiodide treatment is often carried out for complete ablation of residual and/or recurrent tumors after total thyroidectomy. Since radioiodide is actively accumulated via the sodium/iodide symporter (NIS), enhancement of its expression is critical to target cancer cells with radioiodide. To investigate if protein synthesis inhibitors induced endogenous NIS expression in human cancer cells, we evaluated the effects of translation inhibitors, cycloheximide (CHX) and homoharringtonine (HHT), on the NIS expression in MCF-7 breast cancer cells, MKN45 gastric cancer cells, and BHP 2-7 papillary thyroid cancer cells. CHX significantly upregulated NIS mRNA expression in MCF-7 cells (up to -397-fold; EC50, -4.9 μg/mL), as well as MKN45 cells (up to 82-fold; EC50, 43.8 μg/mL), but not BHP 2-7 cells. Iodide uptake was also significantly increased (-1.7-fold) in MCF-7 cells. HHT, an anti-leukemic agent, induced NIS expression in MCF-7 cells (up to -38-fold; EC50, 24.6 ng/mL), MKN45 cells (-9-fold; EC50, 256 ng/mL), and BHP 2-7 cells (-100 fold; EC50, 767 ng/mL). The induction of NIS by CHX in MCF-7 cells, as well as that by HHT in MKN45 cells, were susceptible to p38 MAPK inhibition. To our knowledge, this is the first report demonstrating the induction of NIS by protein synthesis inhibitors in human cancer cells. Further elucidation would uncover more specific, and thus less toxic molecular targets for the enhancement of NIS expression, expecting radioiodide therapy with higher efficacy and safety. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Dokkyo Medical Society |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2436-522X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.51040/dkmj.2023-015 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-3-1-2.pdf (468 KB)
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