| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Claudin 18.2 Inhibits the Proliferation of Small-Cell Lung Cancer Cells via G0/G1 Cell-Cycle Arrest |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
small-cell lung cancer |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
claudin |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cell proliferation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cell-cycle arrest |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CRISPR-Cas9 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kashiwagi, Korehito
Miyazawa, Tadasuke
Sato-Yazawa, Hanako
Ishii, Jun
Kohno, Kakeru
Konno, Koudai
Miyata-Hiramatsu, Chie
Kamimura, Tamotsu
Miyata, Shunsuke
Yazawa, Takuya
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 1,
p. 16-23,
発行日 2024-03-25
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| 記事種別 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Claudin (CLDN) 18.2, a member of the CLDN family, contains tight junctions that regulate the physiological functions of epithelial cells, such as cell differentiation, proliferation, and polarity. CLDN18.2 is also expressed, and performs various functions, in several cancers; however, its expression and function in small-cell lung cancer (SCLC) have not been elucidated. Herein, we determined the expression of CLDN18.2 in SCLC cell lines using quantitative RT-PCR and western blotting. Moreover, we established inducible CLDN18.2 expression SCLC cells and CLDN18.2 knockout SCLC cells and showed that CLDN18.2 inhibited the proliferation of SCLC via G0/G1 cell-cycle arrest using cell-proliferation assay and cell-cycle analysis. This cell-cycle arrest was caused by downregulation of CCND1 and induction of CDKN1A. The present study evokes research interest in CLDN18.2 as a potential therapeutic target and prognostic marker in SCLC, paving the way for future research prospects. |
|
言語 |
en |
| 出版者 |
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出版者 |
Dokkyo Medical Society |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2436-522X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.51040/dkmj.2023-021 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-3-1-3.pdf (322 KB)
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