| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Ovariectomy-Induced Dry Skin Increases IL-31-Induced Scratching Behavior in Mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
dry skin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-13 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-31 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IL-4 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
pruritus |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kawai, Rana
Ichimasu, Nao
Katagiri, Kazumoto
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 2,
p. 105-111,
発行日 2024-06-25
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| 記事種別 |
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Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Dry skin and type 2 cytokines, IL-4/IL-13 and IL-31, have been reported to be involved in pruritus in skin diseases such as atopic dermatitis. IL-31 directly induces pruritus, but IL-4/IL-13 themselves have little or no potential to induce pruritus, whereas IL-4/IL-13 potentiate nerve activation by subthreshold doses of pruritogens such as histamine and IL-31 in vitro, and are involved in alloknesis in dry skin mouse models induced by ovariectomy and artificial barrier disruption. In this study, we investigated whether ovariectomy-induced dry skin with permeability barrier dysfunction enhances IL-31-induced pruritus in mice. Levels of spontaneous scratching behavior were higher than in ovariectomized mice than in sham-operated mice probably due to barrier disruption that could be accelerated by hair shaving. Levels of scratching behavior induced by intradermal administration of IL-31, regardless of single or repeated administration, were increased in ovariectomized mice compared to in sham-operated mice. Pre-intradermal administration of neutralizing antibodies against IL-4/IL-13 did not attenuate the level of IL-31-induced scratching behavior in ovariectomized mice. Our results show that the dry skin induced by ovariectomy is an itchy condition prone to pruritus, and this is the first report showing that the dry skin enhances the potential of IL-31 to induce pruritus in vivo. |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 他の資源との関係 |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2023-051 |
DKMJ-3-2-4.pdf (774 KB)
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