| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Details of Patients Hospitalized with COVID-19 in a University-affiliated Core Hospital and the Changes in Anti-SARS-CoV-2 Antibody Titers of the Physicians Exclusively Responsible for Their Treatment |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
COVID-19 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IgG N antibodies |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
IgG S antibodies |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PPE |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SARS-CoV-2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_0640/ |
|
資源タイプ |
journal |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sugitate, Kei
Fukushima, Yasutsugu
Azuma, Hayase
Ito, Yukari
Takahashi, Tomomi
Irokawa, Masahiro
Kitajima, Ryo
Koyama, Kenya
Hasegawa, Ryuichi
Hirata, Hirokuni
|
| 書誌情報 |
Dokkyo Medical Journal
巻 3,
号 2,
p. 112-122,
発行日 2024-06-25
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| 記事種別 |
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Original |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Introduction: This study clarifies medical care and outcomes for patients hospitalized with COVID-19 and evaluates SARS-CoV-2 infection risk in healthcare professionals, to contribute to appropriate responses in future outbreaks of emerging infectious diseases.
Methods: In total, 585 patients with COVID-19 were classified by disease severity, and laboratory test findings and treatments were examined. Serum IgG antibodies against SARS-CoV-2 spike protein (IgG S antibodies) and those against nucleocapsid protein (IgG N antibodies) were measured in 21 expert respiratory physicians.
Results: Multiple comparison analysis showed significant differences in body mass index (BMI), white blood cell count (WBC), neutrophil count (Neut), lymphocyte count, lactate dehydrogenase (LDH), C-reactive protein, hemoglobin A1c, ferritin, Krebs von den Lungen-6, and D-dimer depending on disease severity. There were significant differences in BMI, WBC, Neut, LDH, and D-dimer between the severe and critical groups. Times from onset to admission and to start of treatment both increased according to severity and were significantly longer in the critical group. Among critical patients requiring ventilation, times from onset to admission, to start of remdesivir, and to start of systemic steroid therapy were significantly longer in those who died. Serum IgG S and IgG N antibody measurements in the 21 respiratory physicians did not indicate direct SARS-CoV-2 transmission from patients.
Conclusion: We identified laboratory test items predicting severe and critical COVID-19 and demonstrated the importance of prompt administration of antiviral and anti-inflammatory agents after symptom onset. SARS-CoV-2 transmission to medical professionals may be prevented by adherence to wearing personal protective equipment. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 他の資源との関係 |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2023-052 |
DKMJ-3-2-5.pdf (247 KB)
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