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Preemptive Medicine for Diabetes from the Viewpoint of the DOHaD Theory
https://dmu.repo.nii.ac.jp/records/2000370
https://dmu.repo.nii.ac.jp/records/2000370a7ccf241-0086-4f24-8e51-85dc4a75246f
| 名前 / ファイル | ライセンス | アクション |
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DKMJ-3-3-1.pdf (368 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| タイトル | ||||||||
| タイトル | Preemptive Medicine for Diabetes from the Viewpoint of the DOHaD Theory | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Developmental Origins of Health and Disease (DOHaD) | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | Diabetes | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | epigenetics | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | preemptive medicine | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| 主題 | life-course medicine | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
Hashimoto, Koshi
× Hashimoto, Koshi
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 3, 号 3, p. 169-177, 発行日 2024-09-25 |
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| 記事種別 | ||||||||
| 値 | Review | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The Developmental Origins of Health and Disease (DOHaD) theory posits that prenatal and infancy environmental factors influence future health and disease susceptibility. Epidemiological and animal studies reveal that factors like nutritional status, maternal illness, chemical exposure, and drug use during pregnancy influence offspring's diabetes risk. Low birthweight correlates with later cardiovascular diseases (Barker's theory), later expanded into DOHaD theory. Dutch Famine links fetal malnutrition to adult diabetes. Animal studies replicating prenatal undernutrition show insulin resistance and altered gene expression. Maternal hypernutrition studies using high-lipid or high-fructose diets demonstrate offspring's increased diabetes risk. Gestational Diabetes Mellitus (GDM) research shows maternal hyperglycemia affects offspring's glucose tolerance. Other maternal factors like deficiency in zinc, vitamin D, sleep disturbances, endocrine disruptor exposure, and substance intake contribute to diabetes risk. Paternal factors, including protein restriction, high-lipid diets, and hyperglycemia, also affect offspring's diabetes risk, possibly through DNA methylation. Pathogenesis involves oxidative stress, gut microbiota, and nutrient-sensing signal disruption. Reprogramming efforts involve interventions during pregnancy or infancy, including antioxidants, green tea, flavonoids, melatonin, resveratrol, and folic acid. The concept of "preemptive medicine" is introduced for diabetes prevention. The "First 1000 days" from fetal life to age 2 and adolescence to young adulthood are critical periods. Understanding epigenomic memory's role and promoting life-course medicine is crucial for preemptive diabetes treatment. Epigenetics, especially DNA methylation, emerges as a key molecular mechanism. Reprogramming epigenomic memory becomes a potential therapy. Overall, this review underscores the importance of comprehensive approaches for diabetes prevention in the context of DOHaD theory. |
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| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Dokkyo Medical Society | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2436-522X | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12941861 | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 他の資源との関係 | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2023-043 | |||||||
