| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Therapeutic Outcome of Chemoradiotherapy with Dose-reduced Nedaplatin and 5-Fluorouracil in Older Esophageal Cancer Patients Aged 80 or More |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chemoradiotherapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
esophageal cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
5-fluorouracil |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nedaplatin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
older adult patient |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Nakajima, Masanobu
Muroi, Hiroto
Kikuchi, Maiko
Kubo, Tsukasa
Takise, Shuhei
Inoue, Noboru
Ihara, Keisuke
Nakagawa, Masatoshi
Morita, Shinji
Nakamura, Takatoshi
Konishi, Kei
Ejima, Yasuo
Kojima, Kazuyuki
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 3,
p. 206-214,
発行日 2024-09-25
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| 記事種別 |
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|
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Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: There is no standard treatment modality for older patients with esophageal cancer, especially those aged ≥ 80 years. At our institution, a decreased dose of nedaplatin plus 5-fluorouracil (NF) was usually used as a regimen of definitive chemoradiotherapy (CRT) for older adult patients. Therefore, this study aimed to analyze the feasibility and effectiveness of definitive CRT with NF (NF-RT) in older adult patients aged 80 years.
Methods: Twenty-eight patients who underwent NF-RT were retrospectively analyzed for therapeutic outcomes and compared with 19 patients who underwent esophagectomy.
Results: Although the NF dose was restricted to 26 (92.9%) patients, 25 patients (89.3%) received a total of 60 Gy of irradiation. The rates of complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were 75.0%, 14.3%, 3.6%, and 3.6%, respectively. Adverse events greater than grade III occurred in 25.0% of the patients. Regarding esophagectomy, preventive lymphadenectomy was contraindicated. The 1-, 2-, and 5-year overall survival of the NF-RT and surgery groups were 74.7%, 67.0%, and 50.0% and 68.4%, 42.1%, and 18.9% (P = 0.0605); 1-, 2-, and 5-year disease-free survival were 79.6%, 75.2%, and 64.4% and 51.0%, 43.7%, and 43.7% (P = 0.0928); and the disease-specific survival were 87.4%, 83.0%, and 72.3% and 72.2%, 60.0%, and 42.0% (P = 0.0832), respectively.
Conclusions: The therapeutic outcome of NF-RT in older patients with esophageal cancer aged ≥ 80 years was favorable. Thus, we think that this is an useful therapeutic modality. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 他の資源との関係 |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2023-059 |
DKMJ-3-3-5.pdf (190 KB)
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