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  1. Dokkyo Medical Journal
  2. 3(3) 2024

A Case of a Subcapsular Abscess of the Liver Caused by Sclerosing Cholangitis Due to Pembrolizumab

https://dmu.repo.nii.ac.jp/records/2000378
https://dmu.repo.nii.ac.jp/records/2000378
d8f7fb76-0a83-41ec-95f4-75e7be15a696
名前 / ファイル ライセンス アクション
DKMJ-3-3-9.pdf DKMJ-3-3-9.pdf (550 KB)
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Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル A Case of a Subcapsular Abscess of the Liver Caused by Sclerosing Cholangitis Due to Pembrolizumab
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Immune checkpoint inhibitor
キーワード
言語 en
主題Scheme Other
主題 Pembrolizumab
キーワード
言語 en
主題Scheme Other
主題 Sclerosing cholangitis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Gyotoku, Yoshinori

× Gyotoku, Yoshinori

en Gyotoku, Yoshinori

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Kuwada, Masaru

× Kuwada, Masaru

en Kuwada, Masaru

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Kobori, Ikuhiro

× Kobori, Ikuhiro

en Kobori, Ikuhiro

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Kusano, Yumi

× Kusano, Yumi

en Kusano, Yumi

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Soga, Koichi

× Soga, Koichi

en Soga, Koichi

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Katayama, Yasumi

× Katayama, Yasumi

en Katayama, Yasumi

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Tamano, Masaya

× Tamano, Masaya

en Tamano, Masaya

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書誌情報 en : Dokkyo Medical Journal

巻 3, 号 3, p. 234-239, 発行日 2024-09-25
記事種別
値 Case Report
内容記述
内容記述タイプ Abstract
内容記述 The patient was a 71-year-old man who was diagnosed with primary lung cancer and was receiving chemotherapy with an immune checkpoint inhibitor. Blood tests performed 2 months after the start of treatment showed elevated hepatobiliary enzymes. Magnetic resonance imaging (MRI) showed multiple bead-like stenoses and dilatations of intrahepatic bile ducts in both lobes of the liver, and liver biopsy was performed to differentiate primary sclerosing cholangitis and drug-induced sclerosing cholangitis caused by immune checkpoint inhibitor treatment (immune-related adverse event (irAE) sclerosing cholangitis). Pathologically, the patient was found to have infiltration of inflammatory cells, mainly lymphocytes, in the portal vein area, consistent with irAE sclerosing cholangitis, and prednisolone therapy was started. Six months after discontinuation of chemotherapy, the patient again showed elevated hepatobiliary enzymes and inflammatory findings. Although the frequency of irAE sclerosing cholangitis itself is very low, when it does occur, it is refractory to treatment and often makes it difficult to continue chemotherapy. In the present case, the patient relapsed 6 months after discontinuation of chemotherapy, suggesting the need for long-term follow-up after discontinuation of the drug. In this report, a case of a subcapsular abscess in the liver caused by sclerosing cholangitis due to pembrolizumab is described.
言語 en
出版者
出版者 Dokkyo Medical Society
ISSN
収録物識別子タイプ EISSN
収録物識別子 2436-522X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12941861
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
他の資源との関係
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.51040/dkmj.2023-049
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