| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
A Case of a Subcapsular Abscess of the Liver Caused by Sclerosing Cholangitis Due to Pembrolizumab |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immune checkpoint inhibitor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pembrolizumab |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Sclerosing cholangitis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Gyotoku, Yoshinori
Kuwada, Masaru
Kobori, Ikuhiro
Kusano, Yumi
Soga, Koichi
Katayama, Yasumi
Tamano, Masaya
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 3,
p. 234-239,
発行日 2024-09-25
|
| 記事種別 |
|
|
|
Case Report |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The patient was a 71-year-old man who was diagnosed with primary lung cancer and was receiving chemotherapy with an immune checkpoint inhibitor. Blood tests performed 2 months after the start of treatment showed elevated hepatobiliary enzymes. Magnetic resonance imaging (MRI) showed multiple bead-like stenoses and dilatations of intrahepatic bile ducts in both lobes of the liver, and liver biopsy was performed to differentiate primary sclerosing cholangitis and drug-induced sclerosing cholangitis caused by immune checkpoint inhibitor treatment (immune-related adverse event (irAE) sclerosing cholangitis). Pathologically, the patient was found to have infiltration of inflammatory cells, mainly lymphocytes, in the portal vein area, consistent with irAE sclerosing cholangitis, and prednisolone therapy was started. Six months after discontinuation of chemotherapy, the patient again showed elevated hepatobiliary enzymes and inflammatory findings. Although the frequency of irAE sclerosing cholangitis itself is very low, when it does occur, it is refractory to treatment and often makes it difficult to continue chemotherapy. In the present case, the patient relapsed 6 months after discontinuation of chemotherapy, suggesting the need for long-term follow-up after discontinuation of the drug. In this report, a case of a subcapsular abscess in the liver caused by sclerosing cholangitis due to pembrolizumab is described. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 他の資源との関係 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2023-049 |
DKMJ-3-3-9.pdf (550 KB)
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