| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
The Improvement of QOL of Caregivers of Patients with Prader-Willi Syndrome after Growth Hormone Therapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Caregiver |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題URI |
deletion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
growth hormone therapy |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Prader-Willi syndrome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
quality of life |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Nakane, Erina
Ogata, Hiroyuki
Saima, Souhei
Kondo, Chuuichi
Gito, Masao
Kobayashi, Sayuki
Oto, Yuji
Murakami, Nobuyuki
Nagai, Toshihiro
Ihara, Hiroshi
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 3,
号 4,
p. 264-271,
発行日 2024-12-25
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| 記事種別 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Prader-Willi syndrome is a rare neurodevelopmental disorder that is characterized by neonatal hypotonia, hypogonadism, hyperphagia, and cognitive impairment. We compared the quality of life of caregivers of patients with Prader-Willi syndrome before and after the patients received growth hormone therapy.
Caregivers' quality of life was assessed using the Japanese version of the World Health Organization Quality of Life 26 (WHO-QOL26). We examined the impacts of two genotypes of Prader-Willi syndrome (deletion and maternal uniparental disomy) and growth hormone therapy on caregivers' quality of life. Using paired t-tests, we compared the caregivers' quality of life scores before and after the patients with Prader-Willi syndrome received growth hormone therapy.
The study included 141 individuals with Prader-Willi syndrome (68 males and 73 females) definitively identified with the deletion genotype and 35 (13 males and 22 females) who exhibited maternal uniparental disomy on chromosome 15. Our findings revealed that the caregivers' quality of life scores of the individuals with Prader-Willi syndrome-deletion before and after growth hormone therapy differed significantly. On the contrary, a statistically significant difference was not noted in all domains of quality of life scores of the caregivers of patients with Prader-Willi syndrome-maternal uniparental disomy on chromosome 15 genotype before and after growth hormone therapy.
The results of this study highlight that the caregivers of individuals with Prader Willi syndrome, particularly those with the Prader-Willi syndrome-deletion genotype receiving growth hormone therapy, had improved quality of life across multiple domains, including physical health, psychological well-being, social connections, and environmental experience. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Dokkyo Medical Society |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2436-522X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2023-063 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-3-4-3.pdf (153 KB)
