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Physiological and Pathophysiological Implications of Tight Junctions in the Liver
https://dmu.repo.nii.ac.jp/records/2000584
https://dmu.repo.nii.ac.jp/records/20005841ed5cef3-7614-4c8c-8ad2-8f431b2f8402
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-4-1-1.pdf (491 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| タイトル | ||||||||||
| タイトル | Physiological and Pathophysiological Implications of Tight Junctions in the Liver | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | liver | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | hepatocytes | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | blood-bile barrier | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | tight junctions | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | polarity | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
Itoh, Masahiko
× Itoh, Masahiko
× Sugimoto, Hiroyuki
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| bibliographic_information |
en : Dokkyo Medical Journal 巻 4, 号 1, p. 1-12, 発行日 2025-03-25 |
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| item_10001_text_33 | ||||||||||
| Review | ||||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The liver is the primary organ for processing nutrients, detoxifying xenobiotics, and excreting bile acids. These essential physiological functions are intricately associated with the structural composition of hepatic tissues. Hepatocytes, the main functional cells of the liver, interconnect to form a complex three-dimensional network of hepatic cords that extends from the periphery to the center of the hepatic lobules. Within these hepatic cords, neighboring hepatocytes create intercellular channel-like structures known as bile canaliculi. These canaliculi serve as pathways through which bile acids are secreted and eventually transported into bile ducts. Tight junctions are integral components of cellular structures that act as barriers and regulate the movement of molecules between cells. In the liver, tight junctions play a crucial role in maintaining the structural integrity of the tissue and in regulating the passage of molecules and ions across hepatocytes and other cells. In addition, tight junctions are essential for establishing and maintaining the polarity of hepatocytes. Because of these important roles, the dysfunction of tight junctions is associated with several liver diseases. In this review, the physiological significance of tight junctions in the liver and their implications in hepatic diseases are described. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Dokkyo Medical Society | |||||||||
| item_10001_source_id_9 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2436-522X | |||||||||
| item_10001_source_id_11 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12941861 | |||||||||
| item_10001_relation_14 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2024-008 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
