| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Non-neutralizing Autoantibodies against Granulocyte-macrophage Colony-stimulating Factor in Patients with Systemic Lupus Erythematosus |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
autoantibody |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
GM-CSF |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SLE |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
connective tissue disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Nagasawa, Junya
Kurasawa, Kazuhiro
Tanaka, Ayae
Yamazaki, Ryutaro
Shimizu, Aya
Komatsu, Sara
Hiyama, Tomoka
Hasegawa, Anna
Miyao, Tomoyuki
Arai, Satoko
Owada, Takayoshi
Arima, Masafumi
Ikeda, Kei
Maezawa, Reika
|
| bibliographic_information |
Dokkyo Medical Journal
巻 4,
号 1,
p. 22-31,
発行日 2025-03-25
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| item_10001_text_33 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that differentiates myeloid cells, mediates tissue damage, and regulates immune response. We previously reported a case of systemic lupus erythematosus (SLE) complicated by pulmonary alveolar proteinosis (PAP) with neutralizing anti-GM-CSF antibodies (Ab). In the present study, we examined the existence of anti-GM-CSF Ab in connective tissue disease (CTD), including SLE without PAP, its neutralizing activity, and the associated clinical features.
Subjects were active SLE, dermatomyositis (DM)/polymyositis (PM), and vasculitis. Enzyme-linked immunosorbent assay was developed to detect anti-GM-CSF Ab. The neutralizing activity of anti-GM-CSF Ab was examined to check if it blocked the increase in GM-CSF stimulated CD11b expression on neutrophils. Anti-GM-CSF Ab was detected in the sera from 44/63 (69.8%) SLE, 23/49 (46.9%) DM/PM, and 14/27 (51.8%) vasculitis patients. Neutralizing activity was not detected in sera with anti-GM-CSF Ab from patients with SLE without PAP, DM/PM, and vasculitis. In SLE, the absence of anti-GM-CSF Ab was associated with serum low complement. A possible association was found between the presence of the Ab and pulmonary involvement in SLE. In summary, non-neutralizing anti-GM-CSF Ab was frequently found in connective tissue diseases, including SLE. The association between the antibody and the clinical features in SLE suggested the possibility that non-neutralizing anti-cytokine antibodies could modify the disease phenotype. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| item_10001_source_id_11 |
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|
収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12941861 |
| item_10001_relation_14 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.51040/dkmj.2024-009 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-1-3.pdf (862 KB)
