| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Nodal Tumor Occupancy Is an Unrecognized but Crucial Prognostic Factor for Postoperative Recurrence in Prostate Cancer Patients with Lymph Node Oligometastases |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
extended pelvic lymph node dissection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
positive node |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
biochemical recurrence-free survival |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tumor burden |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
management options |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Yashi, Masahiro
Imasato, Naoki
Shimoda, Hiroki
Kokubun, Hidetoshi
Nakamura, Gaku
Suzuki, Issei
Takei, Kohei
Kijima, Toshiki
Owada, Atsuko
Ishida, Kazuyuki
Kamai, Takao
|
| bibliographic_information |
en : Dokkyo Medical Journal
巻 4,
号 1,
p. 32-40,
発行日 2025-03-25
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| item_10001_text_33 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Objectives: No well-defined guidelines are in place to manage pathologically node-positive (pN1) cases after definitive surgery for localized prostate cancer. We explored the prognostic value of the nodal tumor burden in positive nodes by offsetting the strong impact of the number of positive nodes.
Methods: Of 389 patients who underwent extended pelvic lymph node dissection (PLND) during robot-assisted radical prostatectomy, 50 (12.9%) patients with ≤ 3 positive nodes were enrolled, excluding those who were clinically node-positive or received neoadjuvant androgen deprivation therapy. Detailed investigations concerning the positive nodes with maximum cancer occupancy (MCO) and largest cancer nest (LCN) size were performed, and their associations with biochemical recurrence (BCR)-free survival were analyzed.
Results: After a median follow-up period of 27.5 months, 28 patients were diagnosed with BCR. International Society of Urological Pathology (ISUP) grade group > 3 at prostatectomy, MCO > 80%, and LCN > 2150μm were significant prognostic factors of BCR. Independent prognostic values were maintained in multivariate models with known factors analyzed separately for the above parameters. The BCR-free survival rate decreased with the increasing number of adverse factors, including surgical margins (model using MCO: not reached to the median with zero risk, 39.0 months with one risk, 15.0 months with two risks, and 1.5 months with three risks).
Conclusions: The tumor burden on the positive node provides independent prognostic value for biochemical recurrence and adds a rationale for selecting management options when PLND has been performed for therapeutic intent and diagnosed with ≤ 3 positive nodes. |
|
言語 |
en |
| 出版者 |
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出版者 |
Dokkyo Medical Society |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| item_10001_source_id_11 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12941861 |
| item_10001_relation_14 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.51040/dkmj.2024-013 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-1-4.pdf (465 KB)
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