| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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タイトル |
Abdominal Ultrasonography Avoids Unnecessary Autopsies in NASH Model Mice |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Animal experimentation |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Colitis |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Fatty liver |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hepatitis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Tumorigenesis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ultrasonography |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Suzuki, Yuto
Hayakawa, Fuki
Soga, Koichi
Ota, Takahiro
Yamaguchi, Mayumi
Tamano, Masaya
|
| bibliographic_information |
en : Dokkyo Medical Journal
巻 4,
号 1,
p. 49-56,
発行日 2025-03-25
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| item_10001_text_33 |
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Original |
| 内容記述 |
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内容記述タイプ |
Abstract |
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内容記述 |
Purpose: The aim of this study was to examine whether abdominal ultrasonography (US) could be used to diagnose fatty liver, hepatic fibrosis, and hepatic tumors in nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) model mice, obviating unnecessary autopsies and increasing the efficiency of research.
Methods: Thirty-eight, 19-week-old, male C57BL/6J mice were used to produce NASH and NAFLD group mice and a control group. US was performed on Day 120, and the mice were then autopsied for histopathological examination and to identify hepatic tumors. Relationships of hepatorenal echo contrast (HEC) and the heterogeneity of liver parenchyma (HOLP) on US with histopathological findings were evaluated.
Results: Histopathological examination confirmed fatty degeneration and hepatic fibrosis in the NAFLD and NASH groups, as did US. The correlation coefficient of the HEC ratio and the fat deposition area showed a significant correlation (0.7295, p < 0.01); the HOLP index showed no correlation with the fat deposition area. Sixteen hepatic tumors were confirmed on autopsy, all in the NASH group, in 9 of 15 mice; of the 16 tumors, 13 (81.2%) were seen on abdominal US. The mean diameter of the tumors imaged was 2.2 ± 0.7 mm, and the mean diameter of the tumors not imaged was 2.9 ± 0.9 mm, with no significant difference (p = 0.2017). The tumors that were not imaged were on the liver periphery or protruding outside the liver from the posterior surface.
Conclusion: This study shows that US can confirm the extent of hepatic fatty degeneration and tumor formation in NASH model mice without autopsy. |
|
言語 |
en |
| 出版者 |
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出版者 |
Dokkyo Medical Society |
| item_10001_source_id_9 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2436-522X |
| item_10001_source_id_11 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12941861 |
| item_10001_relation_14 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.51040/dkmj.2024-022 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-1-6.pdf (1.2 MB)
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